ArticleJournal of bacteriology1996
Interruption of the gpxA gene increases the sensitivity of Neisseria meningitidis to paraquat.
Article in Journal of bacteriology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- The Arsenal ofAntioxidants (Basel, Switzerland) · 2023Review
- Destroying glutathione peroxidase improves the oxidative stress resistance and pathogenicity ofFrontiers in microbiology · 2023Article
- Sepsis: mechanisms of bacterial injury to the patient.Scandinavian journal of trauma, resuscitation and emergency medicine · 2019Review
- Article
- Metabolism and virulence in Neisseria meningitidis.Frontiers in cellular and infection microbiology · 2014Review
- Oxidation-sensing regulator AbfR regulates oxidative stress responses, bacterial aggregation, and biofilm formation in Staphylococcus epidermidis.The Journal of biological chemistry · 2013Article
- Why do bacteria use so many enzymes to scavenge hydrogen peroxide?Archives of biochemistry and biophysics · 2012Review
- Glutamate utilization promotes meningococcal survival in vivo through avoidance of the neutrophil oxidative burst.Molecular microbiology · 2011Article
- The Escherichia coli btuE gene, encodes a glutathione peroxidase that is induced under oxidative stress conditions.Biochemical and biophysical research communications · 2010Article
- AP endonuclease paralogues with distinct activities in DNA repair and bacterial pathogenesis.The EMBO journal · 2007Article
- The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT.Nature biotechnology · 2006Article
- Thioredoxin 1 promotes intracellular replication and virulence of Salmonella enterica serovar Typhimurium.Infection and immunity · 2006Article
- Defenses against oxidative stress in Neisseria gonorrhoeae: a system tailored for a challenging environment.Microbiology and molecular biology reviews : MMBR · 2006Review
- Contribution of glutathione peroxidase to the virulence of Streptococcus pyogenes.Infection and immunity · 2004Article
- Exogenous glutathione completes the defense against oxidative stress in Haemophilus influenzae.Journal of bacteriology · 2003Article
- Nitric oxide metabolism in Neisseria meningitidis.Journal of bacteriology · 2002Article
- Aerotolerance and peroxide resistance in peroxidase and PerR mutants of Streptococcus pyogenes.Journal of bacteriology · 2000Article
- Molecular and biological analysis of eight genetic islands that distinguish Neisseria meningitidis from the closely related pathogen Neisseria gonorrhoeae.Infection and immunity · 2000Article
- Identification and characterization of a new organic hydroperoxide resistance (ohr) gene with a novel pattern of oxidative stress regulation from Xanthomonas campestris pv. phaseoli.Journal of bacteriology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Antioxidant enzymes are thought to be important for the survival of pathogenic Neisseria species. We have further characterized the glutathione peroxidase homolog gene (gpxA), which we recently isolated from Neisseria meningitidis FAM20 (T.D.E. Moore and P.F. Sparling, Infect. Immun. 63:1603-1607, 1995). GpxA was found to be produced constitutively in vivo. An isogenic, omega insertion mutant in the gpxA gene was constructed and characterized. The gpxA insertion mutant was much more sensitive to the oxidative stress caused by paraquat and slightly more sensitive to hydrogen peroxide. This is the first demonstration of a phenotype arising from a mutation of a glutathione peroxidase homolog gene in a prokaryotic organism. Protection of the cell by GpxA from the effects of oxidative stress caused by aerobic metabolism may contribute to the ability of Neisseria meningitidis to cause disease in the human host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.