ReviewThe British journal of cancer. Supplement1996
The molecular response of mammalian cells to hypoxia and the potential for exploitation in cancer therapy.
Review in The British journal of cancer. Supplement, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- The radiomimetic enediyne, 20'-deschloro-C-1027 induces inter-strand DNA crosslinks in hypoxic cells and overcomes cytotoxic radioresistance.DNA repair · 2014Article
- DNA strand cleaving properties and hypoxia-selective cytotoxicity of 7-chloro-2-thienylcarbonyl-3-trifluoromethylquinoxaline 1,4-dioxide.Bioorganic & medicinal chemistry · 2010Article
- C-1027, a radiomimetic enediyne anticancer drug, preferentially targets hypoxic cells.Cancer research · 2009Article
- Hypoxia, angiogenesis and apoptosis markers in locally advanced rectal cancer.International journal of colorectal disease · 2006Article
- Regression of solid tumors by engineered overexpression of von Hippel-Lindau tumor suppressor protein and antisense hypoxia-inducible factor-1alpha.Gene therapy · 2003Article
- NF-kappaB inhibition impairs the radioresponse of hypoxic EMT-6 tumour cells through downregulation of inducible nitric oxide synthase.British journal of cancer · 2003Article
- Relationship of hypoxia to metastatic ability in rodent tumours.British journal of cancer · 2001Article
- Chronic hypoxia modulates tumour cell radioresponse through cytokine-inducible nitric oxide synthase.British journal of cancer · 2001Article
- Gene transfer of antisense hypoxia inducible factor-1 alpha enhances the therapeutic efficacy of cancer immunotherapy.Gene therapy · 2001Article
- Proportion of infiltrating IgG-binding immune cells predict for tumour hypoxia.British journal of cancer · 2001Article
- Development of a hypoxia-responsive vector for tumor-specific gene therapy.Gene therapy · 2000Article
- Novel targets for CNS gene therapy.Gene therapy · 1999Article
- Promoter-activated expression of nerve growth factor for treatment of neurodegenerative diseases.Gene therapy · 1999Review
- An adenoviral vector regulated by hypoxia for the treatment of ischaemic disease and cancer.Gene therapy · 1999Article
- Hypoxia-induced metastasis of human melanoma cells: involvement of vascular endothelial growth factor-mediated angiogenesis.British journal of cancer · 1999Article
- Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast.British journal of cancer · 1999Article
- Molecular chemotherapy for breast cancer.Drugs & aging · 1999Review
- Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix.British journal of cancer · 1998Article
- Energy metabolism in human melanoma cells under hypoxic and acidic conditions in vitro.British journal of cancer · 1997Article
- Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapy.Neoplasia (New York, N.Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
In this review, reports of the increased expression of selected genes in response to hypoxia have been summarised. The best studied mammalian hypoxia response systems are those of the erythropoietin (Epo) and the vascular endothelial growth factor (VEGF) genes, which will be described in some detail. Other genes discussed here include those encoding growth factors, cytokines, transcription factors, metabolic enzymes and DNA repair enzymes. Short DNA sequences (hypoxia response elements) governing the increased gene expression in response to hypoxia have been discovered in the vicinity of most of these genes. The review will end by analysing the possibility of exploiting tumour hypoxia via the use of hypoxia response elements for gene therapy of cancer.
Indexed as
Identifiers
8763864PMC2150030What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.