ArticleJournal of anatomy1996
Innervation of vasculature and microvasculature of the human vagina by NOS and neuropeptide-containing nerves.
Article in Journal of anatomy, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 167 citations in OpenAlex.
- Exploring Localized Provoked Vulvodynia: Insights from Animal Model Research.International journal of molecular sciences · 2024Pooled it
- The Aetiology of Sensory Impairment in Pelvic Organ Prolapse: A Prospective Cohort Study.International urogynecology journal · 2026Article
- The relationship between clitourethrovaginal complex and female orgasm.Archives of gynecology and obstetrics · 2023Review
- Structural and CBCT analysis of mandibular canal microvessels expressing neurotransmitters in human cadavers.Surgical and radiologic anatomy : SRA · 2023Article
- Smooth Muscle Organization and Nerves in the Rat Vagina: A First Look Using Tissue Clearing and Immunolabeling.Annals of biomedical engineering · 2022Article
- Contractile Properties of Vaginal Tissue.Journal of biomechanical engineering · 2020Review
- Understanding sexual arousal and subjective-genital arousal desynchrony in women.Nature reviews. Urology · 2019Review
- Protein kinase enzymes in the human vagina-relation to key mediators of the cyclic AMP and cyclic GMP pathways.International journal of impotence research · 2017Article
- Composite nerve fibers in the hypogastric and pelvic splanchnic nerves: an immunohistochemical study using elderly cadavers.Anatomy & cell biology · 2015Article
- Topohistology of sympathetic and parasympathetic nerve fibers in branches of the pelvic plexus: an immunohistochemical study using donated elderly cadavers.Anatomy & cell biology · 2014Article
- Nerves and fasciae in and around the paracolpium or paravaginal tissue: an immunohistochemical study using elderly donated cadavers.Anatomy & cell biology · 2014Article
- The urethral rhabdosphincter, levator ani muscle, and perineal membrane: a review.BioMed research international · 2014Review
- Norepinephrine potentiates proinflammatory responses of human vaginal epithelial cells.Journal of neuroimmunology · 2013Article
- Systemic and topical hormone therapies reduce vaginal innervation density in postmenopausal women.Menopause (New York, N.Y.) · 2012Article
- Adaptive plasticity of vaginal innervation in term pregnant rats.Reproductive sciences (Thousand Oaks, Calif.) · 2011Article
- Autonomic-somatic communications in the human pelvis: computer-assisted anatomic dissection in male and female fetuses.Journal of anatomy · 2011Article
- PDE-5 and NOS II mRNA expression in menopausal women: a molecular biology study.World journal of urology · 2011Article
- Neurologic factors in female sexual function and dysfunction.Korean journal of urology · 2010Article
- Neutral endopeptidase inhibition: could it have a role in the treatment of female sexual arousal disorder?British journal of pharmacology · 2010Article
- UK-414,495, a selective inhibitor of neutral endopeptidase, potentiates pelvic nerve-stimulated increases in female genital blood flow in the anaesthetized rabbit.British journal of pharmacology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aims of the present study were to determine whether nerves that contain nitric oxide synthase (NOS), calcitonin gene-related peptide (CGRP) or substance P (SP) are present in the human vagina and, if so, to determine the pattern of innervation relative to that of other neurotransmitters, particularly vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY). Surgical specimens of vaginal tissue (n = 10) from pre- and postmenopausal women were fixed and processed for immunohistochemistry of peptides and NOS and for histochemistry of NADPH-diaphorase. SP-immunoreactive nerves were very sparse, being absent from 9 of the 10 tissue samples. For other peptides and NOS, the innervation of the deep arteries and veins was greater than that of blood vessels in the propria. Capillaries in the epithelial papillae also appeared to be innervated by nerves containing NOS, CGRP, NPY and VIP. Beneath the epithelium nerve fibres formed a subepithelial plexus; no nerve cell bodies were seen. The relative density of innervation by immunoreactive fibres was PGP-9.5 > NPY > VIP >> NOS > CGRP > SP. These results imply that nerves that utilise nitric oxide or NPY, VIP or CGRP as a neurotransmitter may play a role in controlling blood flow and capillary permeability in the human vagina. The origin and function of all these nerves is discussed.
Indexed as
Identifiers
8763480PMC1167491W1480732407What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.