ArticleJournal of anatomy1996
Changing expression of intermediate filaments in fibroblasts and cementoblasts of the developing periodontal ligament of the rat molar tooth.
Article in Journal of anatomy, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 25 citations in OpenAlex.
- Histology of human cementum: Its structure, function, and development.The Japanese dental science review · 2016Review
- Hertwig's Epithelial Root Sheath Fate during Initial Cellular Cementogenesis in Rat Molars.Acta histochemica et cytochemica · 2015Article
- Hertwig's epithelial root sheath cell behavior during initial acellular cementogenesis in rat molars.Histochemistry and cell biology · 2014Article
- Multilineage differentiation of dental follicle cells and the roles of Runx2 over-expression in enhancing osteoblast/cementoblast-related gene expression in dental follicle cells.Cell proliferation · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The distributing of vimentin and cytokeratin intermediate filaments within the cells of the dental follicle and developing periodontal ligament is described during eruption of the rat 1st molar tooth. Alcohol-fixed tissues from animals ranging from neonates to 12 wk old were cryosectioned, immunolabelled with monoclonal antibodies against vimentin and a range of cytokeratins and examined by indirect immunofluorescence. Vimentin was observed in follicular and periodontal ligament fibroblasts in all animals and at all stages of eruption. It was also observed in cementoblasts after disruption of the epithelial root sheath (of Hertwig) which is responsible for determining the shape of the developing root. Prior to eruption, cytokeratins were restricted to epithelial components of the developing tooth, including the root sheath. However, they were seen in cementoblasts on disruption of the root sheath at 2 wk and in periodontal ligament fibroblasts at 3 wk after birth, when the tooth was erupting but had not reached occlusion. On occlusion (at 4 wk), fibroblasts no longer labelled for cytokeratins but cementoblasts associated with acellular cementum formation continued to express them. These results demonstrate temporal and spatial changes within the cells of the developing periodontal connective tissues and suggest that the appearance of cytokeratins in periodontal fibroblasts and cementoblasts may be related to mechanical changes during tooth eruption. Further, the results suggest different origins for cementoblasts associated with cellular and acellular cementum formation.
Indexed as
Identifiers
8763470PMC1167481W207880338What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.