ArticleThe Journal of experimental medicine1996
Regulation of pre-T cell receptor (pT alpha-TCR beta) gene expression during human thymic development.
Article in The Journal of experimental medicine, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 71 citations in OpenAlex.
- Pre-TCR-targeted immunotherapy for T cell acute lymphoblastic leukemia.Nature immunology · 2025Article
- T Cell Development: From T-Lineage Specification to Intrathymic Maturation.Advances in experimental medicine and biology · 2025Review
- Chimeric antigen receptor-induced BCL11B suppression propagates NK-like cell development.The Journal of clinical investigation · 2019Article
- A new transcript in the TCRB locus unveils the human ortholog of the mouse pre-Dß1 promoter.Immunity, inflammation and disease · 2017Article
- Expression patterns of Ikaros family members during positive selection and lineage commitment of human thymocytes.Immunology · 2016Article
- Ikaros, Helios, and Aiolos protein levels increase in human thymocytes after β selection.Immunologic research · 2016Article
- Regulation of the transcriptional program by DNA methylation during human αβ T-cell development.Nucleic acids research · 2015Article
- Pre-TCRα supports CD3-dependent reactivation and expansion of TCRα-deficient primary human T-cells.Molecular therapy. Methods & clinical development · 2014Article
- Synergistic effects of interleukin-7 and pre-T cell receptor signaling in human T cell development.The Journal of biological chemistry · 2012Article
- Regulation of in vitro human T cell development through interleukin-7 deprivation and anti-CD3 stimulation.BMC immunology · 2012Article
- Human alpha beta and gamma delta thymocyte development: TCR gene rearrangements, intracellular TCR beta expression, and gamma delta developmental potential--differences between men and mice.Journal of immunology (Baltimore, Md. : 1950) · 2006Article
- Glucose transporter 1 expression identifies a population of cycling CD4+ CD8+ human thymocytes with high CXCR4-induced chemotaxis.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Increased thymocyte CD4+CD8+ cells and T-cell receptor beta gene rearrangements in thymoma.The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi · 2003Article
- An endoplasmic reticulum retention function for the cytoplasmic tail of the human pre-T cell receptor (TCR) alpha chain: potential role in the regulation of cell surface pre-TCR expression levels.The Journal of experimental medicine · 2001Article
- Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors.The EMBO journal · 1999Article
- Identification of a late stage of small noncycling pTalpha- pre-T cells as immediate precursors of T cell receptor alpha/beta+ thymocytes.The Journal of experimental medicine · 1998Article
- One of the CD3epsilon subunits within a T cell receptor complex lies in close proximity to the Cbeta FG loop.The Journal of experimental medicine · 1998Article
- Atomic structure of an alphabeta T cell receptor (TCR) heterodimer in complex with an anti-TCR fab fragment derived from a mitogenic antibody.The EMBO journal · 1998Article
- Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3.The Journal of experimental medicine · 1997Article
- Galectin-1, an endogenous lectin produced by thymic epithelial cells, induces apoptosis of human thymocytes.The Journal of experimental medicine · 1997Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In murine T cell development, early thymocytes that productively rearrange the T cell receptor (TCR) beta locus are selected to continue maturation, before TCR alpha expression, by means of a pre-TCR alpha- (pT alpha-) TCR beta heterodimer (pre-TCR). The aim of this study was to identify equivalent stages in human thymocyte development. We show here that variable-diversity-joining region TCR beta rearrangement and the expression of full-length TCR beta transcripts have been initiated in some immature thymocytes at the TCR alpha/beta- CD4+CD8- stage, and become common in a downstream subset of TCR alpha/beta- CD4+CD8+ thymocytes that is highly enriched in large cycling cells. TCR beta chain expression was hardly detected in TCR alpha/beta- CD4+CD8- thymocytes, whereas cytoplasmic TCR beta chain was found in virtually all TCR alpha/beta- CD4+CD8+ blasts. In addition, a TCR beta complex distinct from the mature TCR alpha/beta heterodimer was immunoprecipitated only from the latter subset. cDNA derived from TCR alpha/beta- CD4+CD8+ blasts allowed us to identify and clone the gene encoding the human pT alpha chain, and to examine its expression at different stages of thymocyte development. Our results show that high pT alpha transcription occurs only in CD4+CD8- and CD4+CD8+ TCR alpha/beta- thymocytes, whereas it is weaker in earlier and later stages of development. Based on these results, we propose that the transition from TCR alpha/beta- CD4+CD8- to TCR alpha/beta- CD4+CD8+ thymocytes represents a critical developmental stage at which the successful expression of TCR beta promotes the clonal expansion and further maturation of human thymocytes, independent of TCR alpha.
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