ArticleThe Journal of experimental medicine1996
Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation.
Article in The Journal of experimental medicine, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 83 citations in OpenAlex.
- Interaction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1 dimerization and SHP-2 activation.Communications biology · 2020Article
- Molecular mechanisms of T-cell tolerance.Immunological reviews · 2011Review
- Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?Journal of translational medicine · 2011Article
- Molecular mechanisms for adaptive tolerance and other T cell anergy models.Seminars in immunology · 2007Review
- Cyclin-dependent kinases: molecular switches controlling anergy and potential therapeutic targets for tolerance.Seminars in immunology · 2007Review
- Physiologic regulation of central and peripheral T cell tolerance: lessons for therapeutic applications.Journal of molecular medicine (Berlin, Germany) · 2006Review
- Defective T cell receptor-mediated signal transduction in memory CD4 T lymphocytes exposed to superantigen or anti-T cell receptor antibodies.Cellular immunology · 2006Article
- Simian immunodeficiency virus Nef protein delays the progression of CD4+ T cells through G1/S phase of the cell cycle.Journal of virology · 2002Article
- Defective dendritic cell maturation in a child with nucleotide excision repair deficiency and CD4 lymphopenia.Clinical and experimental immunology · 2001Article
- Glucocorticoids attenuate T cell receptor signaling.The Journal of experimental medicine · 2001Article
- T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- IL-10-producing T cells suppress immune responses in anergic tuberculosis patients.The Journal of clinical investigation · 2000Article
- Differential T-cell antigen receptor signaling mediated by the Src family kinases Lck and Fyn.Molecular and cellular biology · 2000Article
- Molecular characterization of U937-dependent T-cell co-stimulation.Immunology · 1999Article
- FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Genetic evidence of a role for Lck in T-cell receptor function independent or downstream of ZAP-70/Syk protein tyrosine kinases.Molecular and cellular biology · 1998Article
- Alloantigen-induced unresponsiveness in cord blood T lymphocytes is associated with defective activation of Ras.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Biochemical features of anergic T cells.Immunologic research · 1998Review
- Impaired plasma membrane targeting of Grb2-murine son of sevenless (mSOS) complex and differential activation of the Fyn-T cell receptor (TCR)-zeta-Cbl pathway mediate T cell hyporesponsiveness in autoimmune nonobese diabetic mice.The Journal of experimental medicine · 1997Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
When stimulated through their antigen receptor, without costimulation, T cells enter a state of antigen-specific unresponsiveness, termed anergy. B7-mediated costimulation, signaling via CD28, is sufficient to prevent the induction of anergy. Here we show that ligation of T cell receptor (TCR) by alloantigen alone, which results in anergy, activates tyrosine phosphorylation of TCR zeta and its association with fyn. In contrast, TCR ligation in the presence of B7 costimulation, which results in productive immunity, activates tyrosine phosphorylation of TCR zeta and CD3 chains, which associate with activated lck and zeta-associated protein (ZAP) 70. Under these conditions, CD28 associates with activated lck and TCR zeta. These data suggest that the induction of anergy is an active signaling process characterized by the association of TCR zeta and fyn. In addition, CD28-mediated costimulation may prevent the induction of anergy by facilitating the effective association of TCR zeta and CD3 epsilon with the critical protein tyrosine kinase lck, and the subsequent recruitment of ZAP-70. Strategies to inhibit or activate TCR-associated, specific protein tyrosine kinase-mediated pathways may provide a basis for drug development with potential applications in the fields of transplantation, autoimmunity, and tumor immunity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.