Evidence map›Paper›PMID 8759875›Full record

ArticleJournal of bacteriology1996

Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli.

W A Rosche, A Jaworski, S Kang, S F Kramer, J E Larson, D P Geidroc, R D Wells, R R Sinden

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 43 citations in OpenAlex.

  1. Slippage reconfiguration of trinucleotide repeat hairpins impedes resolution by human replication protein A.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  3. Article
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  9. Short-sequence DNA repeats in prokaryotic genomes.Microbiology and molecular biology reviews : MMBR · 1998
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

W A RoscheDepartment of Biochemistry and Biophysics, Texas A&M University, Texas Medical Center, Houston 77030-3303, USA.
A Jaworski
S Kang
S F Kramer
J E Larson
D P Geidroc
R D Wells
R R Sinden
Texas Medical Center · US

Funding

SPONTANEOUS MUTAGENESIS OF TRIPLET REPEATSP01GM052982 · NIGMS · TEXAS AGRILIFE RESEARCH · PI KLYSIK, JAN E · 1995 to 1999
–
NIEHS NIH HHS ES 05508NIGMS NIH HHS GM 52982
6 · The paper itself

Abstract

The stability of CTG triplet repeats was analyzed in Escherichia coli to identify processes responsible for their genetic instability. Using a biochemical assay for stability, we show that the absence of single-stranded-DNA-binding protein leads to an increase in the frequency of large deletions within the triplet repeats.

Indexed as

PlasmidsTrinucleotide RepeatsBinding SitesDNA-Binding ProteinsEscherichia coliHumansMyotonic DystrophySequence DeletionDNA-Binding Proteins

Identifiers

PMID8759875
PMCPMC178294
OpenAlexW2097382669

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.