ArticleNucleic acids research1996
DNA bending by the silencer protein NeP1 is modulated by TR and RXR.
Article in Nucleic acids research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 50 citations in OpenAlex.
- CTCF shapes chromatin structure and gene expression in health and disease.EMBO reports · 2022Review
- Article
- CTCF mediates chromatin looping via N-terminal domain-dependent cohesin retention.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Choice of binding sites for CTCFL compared to CTCF is driven by chromatin and by sequence preference.Nucleic acids research · 2018Article
- CTCF-Induced Circular DNA Complexes Observed by Atomic Force Microscopy.Journal of molecular biology · 2018Article
- Article
- CTCF: making the right connections.Genes & development · 2016Review
- CO(2)-cAMP-responsive cis-elements targeted by a transcription factor with CREB/ATF-like basic zipper domain in the marine diatom Phaeodactylum tricornutum.Plant physiology · 2012Article
- The CTCF insulator protein forms an unusual DNA structure.BMC molecular biology · 2010Article
- CTCF regulates the local epigenetic state of ribosomal DNA repeats.Epigenetics & chromatin · 2010Article
- The CTCF insulator protein is posttranslationally modified by SUMO.Molecular and cellular biology · 2009Article
- Chromatin insulators: regulatory mechanisms and epigenetic inheritance.Molecular cell · 2008Review
- CTCF mediates insulator function at the CFTR locus.The Biochemical journal · 2007Article
- CTCF is conserved from Drosophila to humans and confers enhancer blocking of the Fab-8 insulator.EMBO reports · 2005Article
- Parent-of-origin-specific binding of nuclear hormone receptor complexes in the H19-Igf2 imprinting control region.Molecular and cellular biology · 2004Article
- Thyroid hormone-regulated enhancer blocking: cooperation of CTCF and thyroid hormone receptor.The EMBO journal · 2003Article
- Differential effect of zinc finger deletions on the binding of CTCF to the promoter of the amyloid precursor protein gene.Nucleic acids research · 2000Article
- Structural and functional conservation at the boundaries of the chicken beta-globin domain.The EMBO journal · 2000Article
- Transcriptional repression by the insulator protein CTCF involves histone deacetylases.Nucleic acids research · 2000Article
- Transcriptional control and the role of silencers in transcriptional regulation in eukaryotes.The Biochemical journal · 1998Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NeP1 binds to the F1 silencer element of the chicken lysozyme gene and, in the presence of TR, v-ERBA or RAR, synergistically represses transcriptional activity. This repression involves a silencing mechanism acting independently of the relative promoter position. Here we show that NeP1 alone can induce a significant directed bend on DNA. The chicken homologue of human NeP1, CTCF, shows identical binding and bending properties. In contrast, the isolated DNA binding domain of CTCF efficiently binds DNA, but fails to confer bending. Similarly, the TR-RXR hetero- or homodimer, binding adjacent to NeP1 at the F2 sequence, do not show significant DNA bending. The binding of the T3 ligand to TR changes neither the magnitude nor the direction of the NeP1 induced bend. However, when all factors are bound simultaneously as a quaternary complex, the TR-RXR heterodimer changes the location of the bend center, the flexure angle and the bending direction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.