ArticleJournal of Tongji Medical University = Tong ji yi ke da xue xue bao1996
ALP induction by beta-glycerophosphate during the non-mineralization phase in vitro.
Article in Journal of Tongji Medical University = Tong ji yi ke da xue xue bao, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 citing papers in PubMed, 4 citations in OpenAlex.
- Comparison on the effects of three sex hormones on the fetal rat calvarial osteoblasts.Journal of Tongji Medical University = Tong ji yi ke da xue xue bao · 2000Article
- Induction of osteocalcin gene expression in vitro by progesterone.Journal of Tongji Medical University = Tong ji yi ke da xue xue bao · 1997Article
- Differentiation of osteoblast in vitro is regulated by progesterone.Journal of Tongji Medical University = Tong ji yi ke da xue xue bao · 1996Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
beta-GP influences on rat osteoblast development at the early period of culture i.e., the non-mineralization phase, and changes with the different cell passages were investigated. Alkaline phosphatase (ALP) was chosen as a main object. Northern blot analysis revealed up to two-fold increase in the steady state level of ALP mRNA after stimulation of rat osteoblast with 10 mM beta-GP. Likewise, 10 mM beta-GP induced a 10-30% increase in ALP activity (P < 0.01) of early passages (1 to 4), but not of later passages (5 to 6). The beta-GP induced increase in ALP activity was totally inhibited by the protein synthesis inhibitor, cycloheximide (50 microM). beta-GP stimulation was found to be without effect on cell proliferation measured as 3H-thymidine incorporation. It is concluded that beta-GP has no effect on proliferation but induces an increase in both mRNA level and activity of ALP in the non-mineralization phase of cultures of fetal rat calvarial cells, which lasts for several passages but will disappear in older cultures.
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