ArticleInfection and immunity1996
Intact immune defenses are required for mice to resist the ts-4 vaccine strain of Toxoplasma gondii.
Article in Infection and immunity, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- d-amino acid oxidase promotes cellular senescence via the production of reactive oxygen species.Life science alliance · 2019Article
- Identification of cellular senescence-specific genes by comparative transcriptomics.Scientific reports · 2016Article
- Establishment of tumor-associated immunity requires interaction of heat shock proteins with CD91.Cancer immunology research · 2014Article
- Kinetics and phenotype of vaccine-induced CD8+ T-cell responses to Toxoplasma gondii.Infection and immunity · 2009Article
- cDNA microarray analysis of host-pathogen interactions in a porcine in vitro model for Toxoplasma gondii infection.Infection and immunity · 2006Article
- Lack of IL-15 results in the suboptimal priming of CD4+ T cell response against an intracellular parasite.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Experimental ocular toxoplasmosis in genetically susceptible and resistant mice.Infection and immunity · 2005Article
- The use of CpG as an adjuvant to Toxoplasma gondii vaccination.Parasitology research · 2004Article
- Respiratory reovirus 1/L induction of intraluminal fibrosis, a model of bronchiolitis obliterans organizing pneumonia, is dependent on T lymphocytes.The American journal of pathology · 2003Article
- Neutrophil depletion during Toxoplasma gondii infection leads to impaired immunity and lethal systemic pathology.Infection and immunity · 2001Article
- Interleukin-12, dendritic cells, and the initiation of host-protective mechanisms against Toxoplasma gondii.The Journal of experimental medicine · 1997Article
- LY6D-induced macropinocytosis as a survival mechanism of senescent cells.The Journal of biological chemistryArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The ts-4 strain of Toxoplasma gondii is a temperature-sensitive mutant that fails to grow at 40 degrees C in vitro. Unlike mildly virulent cyst-forming strains, which can cause fatal chronic infections in certain mouse strains, ts-4 has been widely used to vaccinate mice against virulent T. gondii and is a valuable tool with which to investigate mechanisms of acquired resistance to this parasite. In this report, the basis for the avirulence of ts-4 is analyzed. It is shown that ts-4 is able to persist long-term in vivo in mildly immunocompromised mice, which rules out an intrinsic growth defect as a reason for avirulence. ts-4 does not induce body temperatures in mice as high as that needed to kill it in vitro. Moreover, the mild fevers elicited in resistant B6 mice are also seen in susceptible C57BL/6 scid/scid mice. However, ts-4 elicits strong preimmune defenses, dependent on gamma interferon, which are needed by mice to survive acute infection. Furthermore, CD4+ and CD8+ T-cell-dependent acquired immunity is essential for long-term survival of ts-4-infected mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.