ArticleInfection and immunity1996
Cytokine production by human epithelial and endothelial cells following exposure to oral viridans streptococci involves lectin interactions between bacteria and cell surface receptors.
Article in Infection and immunity, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 81 citations in OpenAlex.
- Oral streptococci: modulators of health and disease.Frontiers in cellular and infection microbiology · 2024Review
- Review
- The Multifaceted Nature of Streptococcal Antigen I/II Proteins in Colonization and Disease Pathogenesis.Frontiers in microbiology · 2020Review
- Microbial functional amyloids serve diverse purposes for structure, adhesion and defence.Biophysical reviews · 2019Review
- Article
- Getting to the heart of the matter: Role of Streptococcus mutans adhesin Cnm in systemic disease.Virulence · 2017Article
- Plasma cytokine levels and risks of abdominal aortic aneurysms: A population-based prospective cohort study.Annals of medicine · 2015Article
- Rapid detection of S. mutans surface antigen I/II using a sensitive monoclonal anti-Ag I/II antibody by ELISA.Monoclonal antibodies in immunodiagnosis and immunotherapy · 2013Article
- An evolving new paradigm: endothelial cells--conditional innate immune cells.Journal of hematology & oncology · 2013Review
- Identification of trans-sialidases as a common mediator of endothelial cell activation by African trypanosomes.PLoS pathogens · 2013Article
- Multispecies biofilms and host responses: "discriminating the trees from the forest".Cytokine · 2013Review
- Epithelial interleukin-8 responses to oral bacterial biofilms.Clinical and vaccine immunology : CVI · 2011Article
- Streptococcus cristatus attenuates Fusobacterium nucleatum-induced cytokine expression by influencing pathways converging on nuclear factor-κB.Molecular oral microbiology · 2011Article
- Streptococcus adherence and colonization.Microbiology and molecular biology reviews : MMBR · 2009Review
- Glucosyltransferases of viridans group streptococci modulate interleukin-6 and adhesion molecule expression in endothelial cells and augment monocytic cell adherence.Infection and immunity · 2006Article
- Fusobacterium nucleatum transports noninvasive Streptococcus cristatus into human epithelial cells.Infection and immunity · 2006Article
- Viridans streptococcal septicaemia in neutropenic patients: role of proinflammatory cytokines.Bone marrow transplantation · 2004Article
- Insertional inactivation of pac and rmlB genes reduces the release of tumor necrosis factor alpha, interleukin-6, and interleukin-8 induced by Streptococcus mutans in monocytic, dental pulp, and periodontal ligament cells.Infection and immunity · 2003Article
- Induction of cytokines by glucosyltransferases of streptococcus mutans.Clinical and diagnostic laboratory immunology · 2002Article
- Expression and functional properties of the Streptococcus intermedius surface protein antigen I/II.Infection and immunity · 2001Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to examine the possible implication of human epithelial and endothelial cells in the pathogenesis of various diseases associated with oral viridans streptococci, we tested the immunomodulatory effects of 11 representative strains of oral viridans streptococci on human epithelial KB cells and endothelial cells. We then examined the possible role of two major adhesins from oral viridans streptococci, protein I/II and rhamnose-glucose polymers (RGPs), in this process. In this study we demonstrate that oral viridans streptococci are potent stimulators of interleukin-8 (IL-8) production from KB cells and of IL-6 and IL-8 production from endothelial cells. The ability of protein I/II and RGPs to contribute to these effects was then examined. Using biotinylated protein I/IIf and RGPs from Streptococcus mutans OMZ 175, we showed that these adhesins bind to KB and endothelial cells through specific interactions and that the binding of these molecules initiates the release of IL-8 from KB cells and of IL-6 and IL-8 from endothelial cells. These results suggest that protein I/IIf and RGPs play an important role in the interactions between bacteria and KB and endothelial cells in that similar cytokine profiles are obtained when cells are stimulated with bacteria or surface components. We also provide evidence that protein I/IIf binds to and stimulates KB and endothelial cells through lectin interactions and that N-acetyl neuraminic acid (NANA) and fucose present on cell surface glycoproteins may form the recognition site since binding and cytokine release can be inhibited by dispase and periodate treatment of cells and by NANA and fucose. These results demonstrate that oral viridans streptococci, probably by engaging two cell surface adhesins, exert immunomodulatory effects on human KB and endothelial cells.
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