ArticleInfection and immunity1996
Identification and characterization of the Yersinia enterocolitica gsrA gene, which protectively responds to intracellular stress induced by macrophage phagocytosis and to extracellular environmental stress.
Article in Infection and immunity, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Who cites it
32 citing papers in PubMed, 62 citations in OpenAlex.
- Formation of Sublethally Injured Yersinia enterocolitica, Escherichia coli O157:H7, and Salmonella enterica Serovar Enteritidis Cells after Neutral Electrolyzed Oxidizing Water Treatments.Applied and environmental microbiology · 2018Article
- ER stress-induced aggresome trafficking of HtrA1 protects against proteotoxicity.Journal of molecular cell biology · 2017Article
- The Potential Link between Thermal Resistance and Virulence inFrontiers in veterinary science · 2017Review
- Further characterization of a highly attenuated Yersinia pestis CO92 mutant deleted for the genes encoding Braun lipoprotein and plasminogen activator protease in murine alveolar and primary human macrophages.Microbial pathogenesis · 2015Article
- Influence of PhoP and intra-species variations on virulence of Yersinia pseudotuberculosis during the natural oral infection route.PloS one · 2014Article
- The role of serine protease HtrA in acute ulcerative enterocolitis and extra-intestinal immune responses during Campylobacter jejuni infection of gnotobiotic IL-10 deficient mice.Frontiers in cellular and infection microbiology · 2014Article
- Human and animal isolates of Yersinia enterocolitica show significant serotype-specific colonization and host-specific immune defense properties.Infection and immunity · 2013Article
- Role of Bordetella pertussis RseA in the cell envelope stress response and adenylate cyclase toxin release.Pathogens and disease · 2013Article
- The outer membrane protein A (OmpA) of Yersinia pestis promotes intracellular survival and virulence in mice.Microbial pathogenesis · 2012Article
- Different contributions of HtrA protease and chaperone activities to Campylobacter jejuni stress tolerance and physiology.Applied and environmental microbiology · 2011Article
- Comparative Global Gene Expression Profiles of Wild-Type Yersinia pestis CO92 and Its Braun Lipoprotein Mutant at Flea and Human Body Temperatures.Comparative and functional genomics · 2010Article
- Comparative proteomics analyses reveal the virB of B. melitensis affects expression of intracellular survival related proteins.PloS one · 2009Article
- Yersinia pestis type III secretion system-dependent inhibition of human polymorphonuclear leukocyte function.Infection and immunity · 2008Article
- Burkholderia cenocepacia requires a periplasmic HtrA protease for growth under thermal and osmotic stress and for survival in vivo.Infection and immunity · 2007Article
- The twin arginine translocation system is essential for virulence of Yersinia pseudotuberculosis.Infection and immunity · 2006Article
- Genetic loci of major antigenic protein genes of Edwardsiella tarda.Applied and environmental microbiology · 2005Article
- The HtrA protease of Campylobacter jejuni is required for heat and oxygen tolerance and for optimal interaction with human epithelial cells.Applied and environmental microbiology · 2005Article
- HtrA stress protein is involved in intramacrophagic replication of adherent and invasive Escherichia coli strain LF82 isolated from a patient with Crohn's disease.Infection and immunity · 2005Article
- Legionella dumoffii DjlA, a member of the DnaJ family, is required for intracellular growth.Infection and immunity · 2004Article
- The htrA (degP) gene of Listeria monocytogenes 10403S is essential for optimal growth under stress conditions.Applied and environmental microbiology · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Yersinia enterocolitica is able to resist the microbicidal mechanisms of macrophages and to grow within phagocytic cells. Some bacteria including Y. enterocolitica have been shown to respond to the hostile environment in macrophages by producing a set of stress proteins which are also induced by environmental stresses. To understand the role of stress proteins in intracellular survival of bacteria, we identified and cloned a Y. enterocolitica gene, called gsrA (global stress requirement). The gsrA gene was identified because its insertional inactivation by a transposon resulted in the inability of the organism to grow at an elevated temperature and to survive within macrophages after phagocytosis. The gsrA gene was sequenced and shown to encode a basic, 49,500-Da protein. The GsrA protein shows significant amino acid sequence homology to the HtrA stress protein which was originally identified in Escherichia coli. Furthermore, the genetically defined Y. enterocolitica gsrA mutant was constructed and characterized. The insertional mutation of gsrA resulted in inhibition of growth at temperatures above 39 degrees C and greatly increased susceptibility to oxidative and osmotic stresses. The mutant additionally lost the ability to survive and replicate within macrophages. These results, taken together, indicate that the gsrA gene is an essential component of the protection mechanism employed by Y. enterocolitica, allowing it to respond to the intracellular stress in macrophages as well as extracellular environmental stress.
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