ArticleInfection and immunity1996
Immunity against Yersinia enterocolitica by vaccination with Yersinia HSP60 immunostimulating complexes or Yersinia HSP60 plus interleukin-12.
Article in Infection and immunity, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 69 citations in OpenAlex.
- Immunogenicity of trimeric autotransporter adhesins and their potential as vaccine targets.Medical microbiology and immunology · 2020Review
- A Combined YopB and LcrV Subunit Vaccine Elicits Protective Immunity againstJournal of immunology (Baltimore, Md. : 1950) · 2019Article
- Immunization with recombinant rabies virus expressing Interleukin-18 exhibits enhanced immunogenicity and protection in mice.Oncotarget · 2017Article
- Co-administration of rIpaB domain of Shigella with rGroEL of S. Typhi enhances the immune responses and protective efficacy against Shigella infection.Cellular & molecular immunology · 2015Article
- Serum biomarkers of Burkholderia mallei infection elucidated by proteomic imaging of skin and lung abscesses.Clinical proteomics · 2015Article
- rIL-22 as an adjuvant enhances the immunogenicity of rGroEL in mice and its protective efficacy against S. Typhi and S. Typhimurium.Cellular & molecular immunology · 2015Article
- A eukaryotic expression plasmid carrying chicken interleukin-18 enhances the response to newcastle disease virus vaccine.Clinical and vaccine immunology : CVI · 2015Article
- B-cell epitopes in GroEL of Francisella tularensis.PloS one · 2014Article
- Physiological levels of glucose induce membrane vesicle secretion and affect the lipid and protein composition of Yersinia pestis cell surfaces.Applied and environmental microbiology · 2013Article
- Recombinant GroEL enhances protective antigen-mediated protection against Bacillus anthracis spore challenge.Medical microbiology and immunology · 2013Article
- Role of heat shock proteins in diseases and their therapeutic potential.Indian journal of microbiology · 2011Article
- Article
- Vaccination with heat shock protein 60 induces a protective immune response against experimental Paracoccidioides brasiliensis pulmonary infection.Infection and immunity · 2008Article
- Amniotic fluid heat shock protein 70 concentration in histologic chorioamnionitis, term and preterm parturition.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2008Article
- Cellular and molecular regulation of vaccination with heat shock protein 60 from Histoplasma capsulatum.Infection and immunity · 2002Article
- Identification of major outer surface proteins of Streptococcus agalactiae.Infection and immunity · 2002Article
- Rational live oral carrier vaccine design by mutating virulence-associated genes of Yersinia enterocolitica.Infection and immunity · 1999Article
- Heat shock protein 70 (hsp70) as a major target of the antibody response in patients with pulmonary cryptococcosis.Clinical and experimental immunology · 1999Article
- Role of heat shock proteins in protection from and pathogenesis of infectious diseases.Clinical microbiology reviews · 1999Review
- Heat shock proteins in immune reactions.Folia microbiologica · 1999Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbial heat shock proteins (HSP) are dominant antigens for the host immune response. Because of the high sequence homology between mammalian and microbial HSP, their value as component of a subunit vaccine has been the subject of controversy. Previous work from this laboratory, however, demonstrated for the first time that the adoptive transfer of HSP60-reactive CD4+ alphabeta T-cell clones confers protection against bacterial infection in mice but does not induce autoimmunity. In the present study, we have therefore evaluated the potential role of Yersinia HSP60 (Y-HSP60) as a vaccine in the Yersinia enterocolitica mouse infection model. For this purpose, immunostimulating complexes (ISCOM) which included Y-HSP60 were constructed. Parenteral administration of this vaccine induced high Y-HSP60-specific serum antibody responses as well as T-cell responses. This reaction was parallelled by immunity against a lethal challenge with Y. enterocolitica. In contrast, mucosal application of Y-HSP60-ISCOM failed to induce systemic Y-HSP60-specific T-cell responses and thus failed to induce immunity against yersiniae. Likewise, vaccination with purified recombinant Y-HSP60 induced antibody responses but only weak T-cell responses. Therefore, this vaccination protocol was not protective. However, when interleukin-12 was used as an adjuvant, purified Y-HSP60 induced significant Y-HSP60-specific T-cell responses and thus induced protection against subsequent challenge with yersiniae. These studies suggest that (i) microbial HSP might be promising candidates for the design of subunit vaccines and (ii) interleukin-12 is an efficient alternative adjuvant to ISCOM particles for induction of protective CD4 Th1-cell-dependent immune responses against bacterial pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.