ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1996
Retroviral misexpression of engrailed genes in the chick optic tectum perturbs the topographic targeting of retinal axons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 120 citations in OpenAlex.
- An Update on the Molecular Mechanism of the Vertebrate Isthmic Organizer Development in the Context of the Neuromeric Model.Frontiers in neuroanatomy · 2022Review
- Homeoprotein transduction in neurodevelopment and physiopathology.Science advances · 2020Review
- Clinical Phenotypes Associated to Engrailed 2 Gene Alterations in a Series of Neuropediatric Patients.Frontiers in neuroanatomy · 2018Article
- En1 is necessary for survival of neurons in the ventral nuclei of the lateral lemniscus.Developmental neurobiology · 2016Article
- Engrailed homeoproteins in visual system development.Cellular and molecular life sciences : CMLS · 2015Review
- Review
- Engrailed alters the specificity of synaptic connections of Drosophila auditory neurons with the giant fiber.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Regulation of ephrin-A expression in compressed retinocollicular maps.Developmental neurobiology · 2013Article
- The evolutionary and genetic origins of consciousness in the Cambrian Period over 500 million years ago.Frontiers in psychology · 2013Article
- Auditory responses of engrailed and invected-expressing Johnston's Organ neurons in Drosophila melanogaster.PloS one · 2013Article
- Architecture and development of olivocerebellar circuit topography.Frontiers in neural circuits · 2012Article
- Reph, a regulator of Eph receptor expression in the Drosophila melanogaster optic lobe.PloS one · 2012Article
- En1 and Wnt signaling in midbrain dopaminergic neuronal development.Neural development · 2011Review
- Extracellular Engrailed participates in the topographic guidance of retinal axons in vivo.Neuron · 2009Article
- Article
- Transcriptional control of behavior: engrailed knock-out changes cockroach escape trajectories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Engrailed expression in subsets of adult Drosophila sensory neurons: an enhancer-trap study.Invertebrate neuroscience : IN · 2008Article
- Localization of a novel gene for congenital nonsyndromic simple microphthalmia to chromosome 2q11-14.Human genetics · 2008Article
- Engrailed in cephalopods: a key gene related to the emergence of morphological novelties.Development genes and evolution · 2007Article
- Direct non-cell autonomous Pax6 activity regulates eye development in the zebrafish.Neural development · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We have investigated the role of the homeodomain transcription factor genes En-1 and En-2, homologs of the Drosophila segment polarity gene engrailed, in regulating the development of the retinotopic map in the chick optic tectum. The En proteins are distributed in a gradient along the rostral-caudal axis of the developing tectum, with highest amounts found caudally. Previous evidence suggests that En-1 and En-2 may regulate the polarity of the rostral-caudal axis of the tectum and the subsequent topographic mapping of retinal axons. We have tested this hypothesis by using a recombinant replication-competent retrovirus to overexpress the En-1 or En-2 genes in the developing tectum. Anterograde labeling with the axon tracer Dil was used to analyze the topographic mapping of retinal axons after the time that the retinotectal projection is normally topographically organized. Overexpression of either En-1 or En-2 perturbed the topographic targeting of retinal axons. In En-infected tecta, nasal retinal axons form an abnormally diffuse projection with numerous aberrant axons, branches, and arbors found at topographically incorrect locations, colocalized with domains of viral infection. In contrast, temporal axons did not form a diffuse projection or discrete aberrant arbors; however, many temporal axons were stunted and ended aberrantly rostral to their appropriate TZ, or in other cases either did not enter the tectum or formed a dense termination at its extreme rostral edge. These findings indicate that En-1 and En-2 are involved in regulating the development of the retinotopic map in the tectum. Furthermore, they support the hypothesis that En genes regulate the polarity of the rostral-caudal axis of the tectum, most likely by controlling the expression of retinal axon guidance molecules.
Indexed as
Identifiers
8757262PMC6578875W1588030956What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.