ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1996
Spatially restricted increase in polysialic acid enhances corticospinal axon branching related to target recognition and innervation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 84 citations in OpenAlex.
- Lasting changes induced by mild alcohol exposure during embryonic development in BDNF, NCAM and synaptophysin-positive neurons quantified in adult zebrafish.The European journal of neuroscience · 2018Article
- Expression of neural cell adhesion molecule and polysialic acid in human bone marrow-derived mesenchymal stromal cells.Stem cell research & therapy · 2016Article
- Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration.Physiological reviews · 2014Review
- Enzymatic engineering of polysialic acid on cells in vitro and in vivo using a purified bacterial polysialyltransferase.The Journal of biological chemistry · 2012Article
- Biodegradable biomatrices and bridging the injured spinal cord: the corticospinal tract as a proof of principle.Cell and tissue research · 2012Review
- Guidance of longitudinally projecting axons in the developing central nervous system.Frontiers in molecular neuroscience · 2012Article
- Article
- Effects of folic acid and homocysteine on spinal cord morphology of the chicken embryo.Histochemistry and cell biology · 2009Article
- Down-regulation of the axonal polysialic acid-neural cell adhesion molecule expression coincides with the onset of myelination in the human fetal forebrain.Neuroscience · 2007Article
- Upregulation of polysialylated neural cell adhesion molecule in the dorsal hippocampus after contextual fear conditioning is involved in long-term memory formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Use of polysialic acid in repair of the central nervous system.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Eph tyrosine kinase receptor EphA4 is required for the topographic mapping of the corticospinal tract.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Pathfinding errors of corticospinal axons in neural cell adhesion molecule-deficient mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Inhibitory mechanism by polysialic acid for lamina-specific branch formation of thalamocortical axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Slit inhibition of retinal axon growth and its role in retinal axon pathfinding and innervation patterns in the diencephalon.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Axon guidance of outgrowing corticospinal fibres in the rat.Journal of anatomy · 1999Review
- Removal of polysialic acid-neural cell adhesion molecule induces aberrant mossy fiber innervation and ectopic synaptogenesis in the hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- The role of glycoproteins in neural development function, and disease.Molecular neurobiology · 1998Review
- Regulation of neural cell adhesion molecule polysialylation: evidence for nontranscriptional control and sensitivity to an intracellular pool of calcium.The Journal of cell biology · 1998Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The polysialic acid (PSA) modification of the neural cell adhesion molecule (NCAM) has been shown to alter the responses of developing axons to their environment. We have studied the potential role of PSA in regulating the innervation of the spinal cord by corticospinal axons, which occurs by a delayed formation of collateral branches from the parent axons. Developmental changes in the distribution of PSA were examined immuno-histochemically using light and electron microscopy. Whereas NCAM is distributed along the entire pathway of rat corticospinal axons as they grow from the cortex to the spinal cord, PSA-modified NCAM does not become evident until later. When PSA becomes evident, it is restricted to the distal segment of these axons from the caudal hindbrain through the spinal cord. The increase in PSA on corticospinal axons coincides with the time that they begin to form collateral branches in the spinal cord. This unique spatiotemporal distribution of PSA suggests its involvement in corticospinal axon branching. To test this hypothesis, PSA was selectively removed by an in vivo injection of endoneuraminidase N. This treatment did not seem to interfere with the pathfinding of corticospinal axons; however, PSA removal delayed the onset of collateral branching by corticospinal axons within the spinal cord and later diminished the magnitude of branching. These findings indicate a role for PSA in the regulation of interstitial axon branching, a crucial step in the process of target recognition and innervation by corticospinal axons.
Indexed as
Identifiers
8757261PMC6578893W1936589222What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.