ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1996
Calcium-dependent paired-pulse facilitation of miniature EPSC frequency accompanies depression of EPSCs at hippocampal synapses in culture.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 129 citations in OpenAlex.
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- Loss of Local Astrocyte Support Disrupts Action Potential Propagation and Glutamate Release Synchrony from Unmyelinated Hippocampal Axon Terminals In Vitro.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Different types of retinal inhibition have distinct neurotransmitter release properties.Journal of neurophysiology · 2015Article
- Prolonged synaptic currents increase relay neuron firing at the developing retinogeniculate synapse.Journal of neurophysiology · 2014Article
- Transcriptome in vivo analysis (TIVA) of spatially defined single cells in live tissue.Nature methods · 2014Article
- Molecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter release.Annual review of physiology · 2014Review
- Tyrosine 402 phosphorylation of Pyk2 is involved in ionomycin-induced neurotransmitter release.PloS one · 2014Article
- Synchronous and asynchronous modes of synaptic transmission utilize different calcium sources.eLife · 2013Article
- Slow changes in Ca2(+) cause prolonged release from GABAergic retinal amacrine cells.Journal of neurophysiology · 2013Article
- Persistent decrease in multiple components of the perineuronal net following status epilepticus.The European journal of neuroscience · 2012Article
- Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor impairs ER Ca(2+) buffering and causes neurodegeneration in primary cortical neurons.Journal of neurochemistry · 2012Article
- Two GABAA responses with distinct kinetics in a sound localization circuit.The Journal of physiology · 2012Article
- Neurotrophin-3 mRNA a putative target of miR21 following status epilepticus.Brain research · 2011Article
- Regulation of exocytic mode in hippocampal neurons by intra-bouton calcium concentration.The Journal of physiology · 2010Article
- Chronic intermittent hypoxia affects integration of sensory input by neurons in the nucleus tractus solitarii.Respiratory physiology & neurobiology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Two forms of evoked neurotransmitter release at excitatory synapses between cultured hippocampal neurons have been described. After an action potential, it has been shown that transmitter initially is released synchronously, and this is followed by a period of "slow" asynchronous release. The "fast" synchronous component of release at these synapses has been found routinely to demonstrate paired-pulse and tetanic depression, whereas the short-term plasticity of asynchronous release has not been investigated. In the present experiments, we have used the whole-cell patch-clamp technique to record from pairs of neurons in a low-density hippocampal culture preparation to determine both the properties and underlying mechanisms of short-term plasticity of asynchronous release. It was found that an increase in miniature EPSC (mEPSC) frequency accompanied both single and multiple stimuli, and this mEPSC increase was facilitated during paired stimuli, even when the evoked synchronous release was depressed. In addition, both the activity-dependent depression of evoked EPSCs and facilitation of asynchronous mEPSC release were dependent on Ca accumulation in the nerve terminal. However, the Ca-dependent mechanisms underlying these two processes could be distinguished by the differential effects of two membrane-permeant calcium chelators, BAPTA-AM and EGTA-AM. Frequency-dependent depression of evoked EPSCs involves a rapid rise in intraterminal Ca, which likely triggers a process that proceeds in a Ca-independent manner, whereas the asynchronous release may be linked more directly to a sustained increase in intraterminal Ca.
Indexed as
Identifiers
8757244PMC6578891W1481927180What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.