ArticleMolecular and cellular biology1996
Enhancement of antiproliferative activity of gamma interferon by the specific inhibition of tyrosine dephosphorylation of Stat1.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 151 citations in OpenAlex.
- Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma.The Journal of clinical investigation · 1999Trial
- Curcumin and its Derivatives Targeting Multiple Signaling Pathways to Elicit Anticancer Activity: A Comprehensive Perspective.Current medicinal chemistry · 2024Review
- Article
- Stat2 stability regulation: an intersection between immunity and carcinogenesis.Experimental & molecular medicine · 2020Review
- Inflammaging: Age and Systemic, Cellular, and Nuclear Inflammatory Biology in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells.Cell communication and signaling : CCS · 2017Review
- The crossroads of breast cancer progression: insights into the modulation of major signaling pathways.OncoTargets and therapy · 2017Review
- Review
- Two glutamic acid residues in the DNA-binding domain are engaged in the release of STAT1 dimers from DNA.BMC cell biology · 2012Article
- Inborn errors of human STAT1: allelic heterogeneity governs the diversity of immunological and infectious phenotypes.Current opinion in immunology · 2012Review
- Knockdown of menin affects pre-mRNA processing and promoter fidelity at the interferon-gamma inducible IRF1 gene.Epigenetics & chromatin · 2012Article
- A novel disrupter of telomere silencing 1-like (DOT1L) interaction is required for signal transducer and activator of transcription 1 (STAT1)-activated gene expression.The Journal of biological chemistry · 2011Article
- Mast cell homeostasis and the JAK-STAT pathway.Genes and immunity · 2010Review
- Disruption of protein arginine N-methyltransferase 2 regulates leptin signaling and produces leanness in vivo through loss of STAT3 methylation.Circulation research · 2010Article
- Menin and RNF20 recruitment is associated with dynamic histone modifications that regulate signal transducer and activator of transcription 1 (STAT1)-activated transcription of the interferon regulatory factor 1 gene (IRF1).Epigenetics & chromatin · 2010Article
- Characterization of a dominant-active STAT that promotes tumorigenesis in Drosophila.Developmental biology · 2010Article
- Protein tyrosine phosphatases in the JAK/STAT pathway.Frontiers in bioscience : a journal and virtual library · 2008Review
- Hypoxic repression of STAT1 and its downstream genes by a pVHL/HIF-1 target DEC1/STRA13.Oncogene · 2007Article
- Dephosphorylation of phosphotyrosine on STAT1 dimers requires extensive spatial reorientation of the monomers facilitated by the N-terminal domain.Genes & development · 2006Article
- Distinct requirements for the naturally occurring splice forms Stat4alpha and Stat4beta in IL-12 responses.The EMBO journal · 2003Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Gamma interferon (IFN-gamma) signals to the nucleus through the activation, by tyrosine phosphorylation, of the latent cytoplasmic transcription factor Stat1 (signal transducer and activator of transcription). It has been demonstrated that the activity of Stat1 is dependent on tyrosine phosphorylation which is regulated by Jak tyrosine kinases as well as by the as-yet-unidentified protein tyrosine phosphatase. We report that the N-terminal domain of Stat1, which is highly conserved among all STAT family members, is required for its tyrosine dephosphorylation. A single amino acid substitution (Arg-31 to Ala) in the Stat1 N-terminal domain inhibited Stat1 tyrosine dephosphorylation. The deletion of the Stat1 N-terminal domain resulted in a mutant Stat1 protein which was constitutively phosphorylated on Tyr-701. Upon IFN-gamma stimulation, the tyrosine phosphorylation of this mutant protein was further enhanced but was not down-regulated by protein tyrosine phosphatase in vivo. When expressed in NIH 3T3 cells, this mutant protein greatly enhanced the antiproliferative activity of IFN-gamma. We suggest that the N-terminal domains of STATs are crucial for modulating STAT activities through regulating the tyrosine dephosphorylation of STATs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.