ArticleMolecular and cellular biology1996
The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 55 citations in OpenAlex.
- Macrophages: Subtypes, Distribution, Polarization, Immunomodulatory Functions, and Therapeutics.MedComm · 2025Review
- Deubiquitinases and Cancer.Journal of pharmacy & bioallied sciences · 2024Review
- USP17 is required for peripheral trafficking of lysosomes.EMBO reports · 2022Article
- Review
- DUB3 deubiquitinates and stabilizes NRF2 in chemotherapy resistance of colorectal cancer.Cell death and differentiation · 2019Article
- Regulatory interplay between deubiquitinating enzymes and cytokines.Cytokine & growth factor reviews · 2019Review
- USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells.Cell communication and signaling : CCS · 2018Article
- Stabilization of the transcription factors slug and twist by the deubiquitinase dub3 is a key requirement for tumor metastasis.Oncotarget · 2017Article
- USP17 is required for clathrin mediated endocytosis of epidermal growth factor receptor.Oncotarget · 2014Article
- Article
- Evidence for OTUD-6B participation in B lymphocytes cell cycle after cytokine stimulation.PloS one · 2011Article
- The role of deubiquitinating enzymes in apoptosis.Cellular and molecular life sciences : CMLS · 2011Review
- The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.BMC genomics · 2010Article
- USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.The Journal of biological chemistry · 2009Article
- Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes.Annual review of biochemistry · 2009Review
- Ubiquitin-dependent mechanism regulates rapid turnover of AU-rich cytokine mRNAs.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14.The EMBO journal · 2001Article
- Tissue-specificity, functional characterization and subcellular localization of a rat ubiquitin-specific processing protease, UBP109, whose mRNA expression is developmentally regulated.The Biochemical journal · 2000Article
- Differential utilization of Ras signaling pathways by macrophage colony-stimulating factor (CSF) and granulocyte-macrophage CSF receptors during macrophage differentiation.Molecular and cellular biology · 1998Article
- Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Cytokines regulate cell growth and differentiation by inducing the expression of specific target genes. We have recently isolated a cytokine-inducible, immediate-early cDNA, DUB-1, that encodes a deubiquitinating enzyme. The DUB-1 mRNA was specifically induced by the receptors for interleukin-3, granulocyte-macrophage colony-stimulating factor, and interleukin-5, suggesting a role for the beta common (betac subunit known to be shared by these receptors. In order to identify the mechanism of cytokine induction, we isolated a murine genomic clone for DUB-1 containing a functional promoter region. The DUB-1 gene contains two exons, and the nucleotide sequence of its coding region is identical to the sequence of DUB-1 cDNA. Various regions of the 5' flanking region of the DUB-1 gene were assayed for cytokine-inducible activity. An enhancer region that retains the beta c-specific inducible activity of the DUB-1 gene was identified. Enhancer activity was localized to a 112-bp fragment located 1.4 kb upstream from the ATG start codon. Gel mobility shift assays revealed two specific protein complexes that bound to this minimal enhancer region. One complex was induced by betac signaling, while the other was noninducible. Finally, the membrane-proximal region of human betac was required for DUB-1 induction. In conclusion, DUB-1 is the first example of an immediate-early gene that is induced by a specific subunit of a cytokine receptor. Further analysis of the DUB-1 enhancer element may reveal specific determinants of a betac-specific signaling pathway.
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