ArticleMolecular and cellular biology1996
Complex architecture of major histocompatibility complex class II promoters: reiterated motifs and conserved protein-protein interactions.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- RFX5 in cancer: context-dependent molecular functions and emerging translational relevance.Frontiers in immunology · 2026Review
- Positive selection in coding regions and motif duplication in regulatory regions of bottlenose dolphin MHC class II genes.PloS one · 2018Article
- Regulation of major histocompatibility complex class II genes.Current opinion in immunology · 2011Review
- Solution structure of the heterotrimeric complex between the interaction domains of RFX5 and RFXAP from the RFX gene regulatory complex.Journal of molecular biology · 2010Article
- Formation of the RFX gene regulatory complex induces folding of the interaction domain of RFXAP.Proteins · 2009Article
- Aberrant MHC class II expression in mouse joints leads to arthritis with extraarticular manifestations similar to rheumatoid arthritis.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Inhibition of MHC II gene transcription by nitric oxide and antioxidants.Current pharmaceutical design · 2004Review
- Novel mechanisms of class II major histocompatibility complex gene regulation.Immunologic research · 2003Review
- Major histocompatibility complex class II transcriptional platform: assembly of nuclear factor Y and regulatory factor X (RFX) on DNA requires RFX5 dimers.Molecular and cellular biology · 2002Article
- Impaired regulation of HLA-DR expression in human immunodeficiency virus-infected monocytes.Clinical and diagnostic laboratory immunology · 2002Review
- Histone deacetylase activity represses gamma interferon-inducible HLA-DR gene expression following the establishment of a DNase I-hypersensitive chromatin conformation.Molecular and cellular biology · 2001Article
- IFN-gamma-dependent transcription of MHC class II IA is impaired in macrophages from aged mice.The Journal of clinical investigation · 2001Article
- Associations and interactions between bare lymphocyte syndrome factors.Molecular and cellular biology · 2000Article
- Class II transactivator: mastering the art of major histocompatibility complex expression.Molecular and cellular biology · 2000Review
- Mutations in the bare lymphocyte syndrome define critical steps in the assembly of the regulatory factor X complex.Molecular and cellular biology · 2000Article
- Interactions between the class II transactivator and CREB binding protein increase transcription of major histocompatibility complex class II genes.Molecular and cellular biology · 1999Article
- The MHC class II transactivator (CIITA) requires conserved leucine charged domains for interactions with the conserved W box promoter element.Nucleic acids research · 1998Article
- Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathway.The Journal of experimental medicine · 1998Article
- Retinoblastoma protein expression facilitates chromatin remodeling at the HLA-DRA promoter.Nucleic acids research · 1997Article
- The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32.Nucleic acids research · 1997Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The S box (also known as at the H, W, or Z box) is the 5'-most element of the conserved upstream sequences in promoters of major histocompatibility complex class II genes. It is important for their B-cell-specific and interferon gamma-inducible expression. In this study, we demonstrate that the S box represents a duplication of the downstream X box. First, RFX, which is composed of the RFX5-p36 heterodimer that binds to the X box, also binds to the S box and its 5'-flanking sequence. Second, NF-Y, which binds to the Y box and increases interactions between RFX and the X box, also increases the binding of RFX to the S box. Third, RFXs bound to S and X boxes interact with each other in a spatially constrained manner. Finally, we confirmed these protein-protein and protein-DNA interactions by expressing a hybrid RFX5-VP16 protein in cells. We conclude that RFX binds to S and X boxes and that complex interactions between RFX and NF-Y direct B-cell-specific and interferon gamma-inducible expression or major histocompatibility complex class II genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.