ArticleMolecular and cellular biology1996
Anchorage-dependent transcription of the cyclin A gene.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 137 citations in OpenAlex.
- Single-cell adhesion strength and contact density drops in the M phase of cancer cells.Scientific reports · 2021Article
- Cell adhesion is regulated by CDK1 during the cell cycle.The Journal of cell biology · 2018Article
- MAPK uncouples cell cycle progression from cell spreading and cytoskeletal organization in cycling cells.Cellular and molecular life sciences : CMLS · 2013Article
- Cdc6 protein activates p27KIP1-bound Cdk2 protein only after the bound p27 protein undergoes C-terminal phosphorylation.The Journal of biological chemistry · 2012Article
- Rho-associated kinase connects a cell cycle-controlling anchorage signal to the mammalian target of rapamycin pathway.The Journal of biological chemistry · 2011Article
- Competitive nuclear export of cyclin D1 and Hic-5 regulates anchorage dependence of cell growth and survival.Molecular biology of the cell · 2009Article
- Human and mouse cyclin D2 splice variants: transforming activity and subcellular localization.Oncogene · 2008Article
- Focal adhesion kinase controls cellular levels of p27/Kip1 and p21/Cip1 through Skp2-dependent and -independent mechanisms.Molecular and cellular biology · 2006Article
- Article
- Loss of cellular adhesion to matrix induces p53-independent expression of PTEN tumor suppressor.BMC molecular biology · 2002Article
- Transcriptional activation of cyclin D1 promoter by FAK contributes to cell cycle progression.Molecular biology of the cell · 2001Article
- Distinct effects of mitogens and the actin cytoskeleton on CREB and pocket protein phosphorylation control the extent and timing of cyclin A promoter activity.Molecular and cellular biology · 2001Article
- Mammary epithelial cell-cycle progression via the alpha(2)beta(1) integrin: unique and synergistic roles of the alpha(2) cytoplasmic domain.The American journal of pathology · 2001Article
- Adhesion-regulated G1 cell cycle arrest in epithelial cells requires the downregulation of c-Myc.Oncogene · 2001Article
- Role of the F-box protein Skp2 in adhesion-dependent cell cycle progression.The Journal of cell biology · 2001Article
- Dual stimulation of Ras/mitogen-activated protein kinase and RhoA by cell adhesion to fibronectin supports growth factor-stimulated cell cycle progression.The Journal of cell biology · 2000Article
- Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions.Genes & development · 2000Article
- Restoration of retinoblastoma mediated signaling to Cdk2 results in cell cycle arrest.Oncogene · 2000Article
- Cyclin D2 overexpression and lack of p27 correlate positively and cyclin E inversely with a poor prognosis in gastric cancer cases.The American journal of pathology · 2000Article
- Regulation of p21(cip1) expression by growth factors and the extracellular matrix reveals a role for transient ERK activity in G1 phase.The Journal of cell biology · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NIH 3T3 cells cultured in suspension fail to express cyclin A and hence cannot enter S phase and divide. We show that loss of cell adhesion to substratum abrogates cyclin A gene expression by blocking its promoter activity through the E2F site that mediates its cell cycle regulation in adherent cells. In suspended cells, G0-specific E2F complexes remain bound to the cyclin A promoter. Overexpression of cyclin D1 restores cyclin A transcription in suspended cells and rescues them from cell cycle arrest. In suspended cells, cyclin D1 and cyclin E accumulate normally upon serum stimulation, but their associated kinases remain inactive; their substrates, pRb and p107, are not hyperphosphorylated. Concomitantly, the cyclin-dependent kinase inhibitor, p27KIP1, is stabilized. Ectopic expression of p27KIP1 blocks cyclin A promoter activity through its EN binding site. These data suggest that the block to cyclin A transcription in nonadherent NIH 3T3 cells results from stabilization of p27KIP1 and subsequent inactivation of the specific E2F moiety required for its induction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.