ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1996
The alpha 1E calcium channel exhibits permeation properties similar to low-voltage-activated calcium channels.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 145 citations in OpenAlex.
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- Mechanism of Manganese Dysregulation of Dopamine Neuronal Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Calcium signalling through L-type calcium channels: role in pathophysiology of spinal nociceptive transmission.British journal of pharmacology · 2018Review
- Identification and Characterization of a G Protein-binding Cluster in α7 Nicotinic Acetylcholine Receptors.The Journal of biological chemistry · 2015Article
- Characterization of slow waves generated by myenteric interstitial cells of Cajal of the rabbit small intestine.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- Lipid modulation of calcium flux through CaV2.3 regulates acrosome exocytosis and fertilization.Developmental cell · 2014Article
- Augmentation of Cav1 channel current and action potential duration after uptake of S100A1 in sympathetic ganglion neurons.American journal of physiology. Cell physiology · 2009Article
- Effects of strontium on the permeation and gating phenotype of calcium channels in hair cells.Journal of neurophysiology · 2008Article
- Differential gating and recruitment of P/Q-, N-, and R-type Ca2+ channels in hippocampal mossy fiber boutons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Molecular determinant for specific Ca/Ba selectivity profiles of low and high threshold Ca2+ channels.The Journal of general physiology · 2007Article
- Zn2+ sensitivity of high- and low-voltage activated calcium channels.Biophysical journal · 2007Article
- FSH stimulates ovarian cancer cell growth by action on growth factor variant receptor.Molecular and cellular endocrinology · 2007Article
- Amino acid substitutions in the pore of the Ca(V)1.2 calcium channel reduce barium currents without affecting calcium currents.Biophysical journal · 2005Article
- R-type calcium channels contribute to afterdepolarization and bursting in hippocampal CA1 pyramidal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Dendritic low-threshold Ca2+ channels in rat cerebellar Purkinje cells: possible physiological implications.Cerebellum (London, England) · 2003Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The physiological and pharmacological properties of the alpha 1E calcium (Ca) channel subtype do not exactly match any of the established categories described for native neuronal Ca currents. Many of the key diagnostic features used to assign cloned Ca channels to their native counterparts, however, are dependent on a number of factors, including cellular environment, beta subunit coexpression, and modulation by second messengers and G-proteins. Here, by examining the intrinsic pore characteristics of a family of transiently expressed neuronal Ca channels, we demonstrate that the permeation properties of alpha 1E closely resemble those described for a subset of low-threshold Ca channels. The alpha 1A (P-/Q-type), alpha 1B (N-type), and alpha 1C (L-type) high-threshold Ca channels all exhibit larger whole-cell currents with barium (Ba) as the charge carrier as compared with Ca or strontium (Sr). In contrast, macroscopic alpha 1E currents are largest in Sr, followed by Ca and then Ba. The unique permeation properties of alpha 1E are maintained at the single-channel level, are independent of the nature of the expression system, and are not affected by coexpression of alpha 2 and beta subunits. Overall, the permeation characteristics of alpha 1E are distinct from those described for R-type currents and share some similarities with native low-threshold Ca channels.
Indexed as
Identifiers
8756429PMC6579290W2129749682What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.