ArticleProceedings of the National Academy of Sciences of the United States of America1996
Formation of junctions involved in excitation-contraction coupling in skeletal and cardiac muscle.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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Who cites it
81 citing papers in PubMed.
- Review
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- From function to structure: how myofibrillogenesis influences the transverse-axial tubular system development and its peculiarities.Frontiers in physiology · 2025Review
- Disrupted T-tubular network accounts for asynchronous calcium release in MTM1-deficient skeletal muscle.The Journal of physiology · 2023Article
- High-intensity interval training remodels the proteome and acetylome of human skeletal muscle.eLife · 2022Article
- CaeLife · 2022Article
- Structural Insight Into Ryanodine Receptor Channelopathies.Frontiers in pharmacology · 2022Review
- Improper Remodeling of Organelles Deputed to CaInternational journal of molecular sciences · 2021Review
- Janus 3D printed dynamic scaffolds for nanovibration-driven bone regeneration.Nature communications · 2021Article
- Article
- Calsequestrin: a well-known but curious protein in skeletal muscle.Experimental & molecular medicine · 2020Review
- Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target.Nature reviews. Cardiology · 2020Review
- Dynamics of triadin, a muscle-specific triad protein, within sarcoplasmic reticulum subdomains.Molecular biology of the cell · 2020Article
- Pediatric Malignant Arrhythmias Caused by Rare Homozygous Genetic Variants inFrontiers in pediatrics · 2020Review
- The binding interactions that maintain excitation-contraction coupling junctions in skeletal muscle.The Journal of general physiology · 2019Article
- Development of the excitation-contraction coupling machinery and its relation to myofibrillogenesis in human iPSC-derived skeletal myocytes.Skeletal muscle · 2018Article
- Shining New Light on the Structural Determinants of Cardiac Couplon Function: Insights From Ten Years of Nanoscale Microscopy.Frontiers in physiology · 2018Review
- Ryanodine receptors are part of the myospryn complex in cardiac muscle.Scientific reports · 2017Article
- Inhibition of CDK5 Alleviates the Cardiac Phenotypes in Timothy Syndrome.Stem cell reports · 2017Article
- The relative contributions of store-operated and voltage-gated CaThe Journal of physiology · 2017Article
21 more citing papers are in PubMed but not listed here.
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2 authors.
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Abstract
During excitation-contraction (e-c) coupling of striated muscle, depolarization of the surface membrane is converted into Ca2+ release from internal stores. This process occurs at intracellular junctions characterized by a specialized composition and structural organization of membrane proteins. The coordinated arrangement of the two key junctional components--the dihydropyridine receptor (DHPR) in the surface membrane and the ryanodine receptor (RyR) in the sarcoplasmic reticulum--is essential for their normal, tissue-specific function in e-c coupling. The mechanisms involved in the formation of the junctions and a potential participation of DHPRs and RyRs in this process have been subject of intensive studies over the past 5 years. In this review we discuss recent advances in understanding the organization of these molecules in skeletal and cardiac muscle, as well as their concurrent and independent assembly during development of normal and mutant muscle. From this information we derive a model for the assembly of the junctions and the establishment of the precise structural relationship between DHPRs and RyRs that underlies their interaction in e-c coupling.
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