ArticleProceedings of the National Academy of Sciences of the United States of America1996
A Ds insertion alters the nuclear localization of the maize transcriptional activator R.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Regulation of Flavonoid Biosynthesis by the MYB-bHLH-WDR (MBW) Complex in Plants and Its Specific Features in Cereals.International journal of molecular sciences · 2025Review
- Transposition behavior of nonautonomous a hAT superfamily transposon nDart in rice (Oryza sativa L.).Molecular genetics and genomics : MGG · 2011Article
- Genome-wide distribution of transposed Dissociation elements in maize.The Plant cell · 2010Article
- Generating novel allelic variation through Activator insertional mutagenesis in maize.Genetics · 2007Article
- Gene conversion within regulatory sequences generates maize r alleles with altered gene expression.Genetics · 2001Article
- Modular domain structure of Arabidopsis COP1. Reconstitution of activity by fragment complementation and mutational analysis of a nuclear localization signal in planta.Plant physiology · 2000Article
- Molecular consequences of Ds insertion into and excision from the helix-loop-helix domain of the maize R gene.Genetics · 1998Article
- Xa21D encodes a receptor-like molecule with a leucine-rich repeat domain that determines race-specific recognition and is subject to adaptive evolution.The Plant cell · 1998Article
- Retrotransposon insertion into the maize waxy gene results in tissue-specific RNA processing.The Plant cell · 1997Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The R-sc gene of maize is a member of the R gene family of transcriptional activators that regulate anthocyanin biosynthesis. A derivative of R-sc, r-m9 conditions a reduced level of aleurone pigmentation due to the presence of a 2.1-kb Ds insertion near the 3' end of the coding region. Excision of Ds from r-m9 leaves a 7-bp insertion in the darker but still mutant v24 derivative. Both the 7-bp insertion in v24 and the 2.1-kb Ds in r-m9 are predicted to truncate their respective R proteins proximal to the carboxyl terminus, which was shown previously to contain one of three nuclear localization sequences. We find that the reduced expression of r-m9 and v24 are not due to mRNA or protein instability, but most likely reflect the inefficient localization of truncated R proteins to the nucleus. To our knowledge this is the first example of a transposable element insertion that alters gene expression by affecting nuclear localization. In addition, our data indicate that the carboxyl terminus of the R protein is far more important than previously suspected and illustrates the utility of natural mutations for defining functional domains in proteins.
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