ArticleProceedings of the National Academy of Sciences of the United States of America1996
P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed, 268 citations in OpenAlex.
- [Growth hormone and fertility: molecular mechanisms and experience of adjuvant therapy in reproductology].Problemy endokrinologii · 2026Review
- Growth hormone in fertility and infertility: Mechanisms of action and clinical applications.Frontiers in endocrinology · 2022Review
- Limb positioning and initiation: An evolutionary context of pattern and formation.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Review
- The transcription factor PITX1 drives astrocyte differentiation by regulating the SOX9 gene.The Journal of biological chemistry · 2020Article
- Pigeon foot feathering reveals conserved limb identity networks.Developmental biology · 2019Article
- African evolutionary history inferred from whole genome sequence data of 44 indigenous African populations.Genome biology · 2019Article
- Dynamic 3D chromatin architecture contributes to enhancer specificity and limb morphogenesis.Nature genetics · 2018Article
- The 2017 ABJS Nicolas Andry Award: Advancing Personalized Medicine for Clubfoot Through Translational Research.Clinical orthopaedics and related research · 2017Article
- Limb development: a paradigm of gene regulation.Nature reviews. Genetics · 2017Review
- Long-chain unsaturated fatty acids reduce the transcriptional activity of the rat follicle-stimulating hormone β-subunit gene.The Journal of reproduction and development · 2016Article
- Functional characterization of a human POU1F1 mutation associated with isolated growth hormone deficiency: a novel etiology for IGHD.Human molecular genetics · 2016Article
- Biophysical Characterization of G-Quadruplex Recognition in the PITX1 mRNA by the Specificity Domain of the Helicase RHAU.PloS one · 2015Article
- Distinct populations within Isl1 lineages contribute to appendicular and facial skeletogenesis through the β-catenin pathway.Developmental biology · 2014Article
- Novel and recurrent PITX3 mutations in Belgian families with autosomal dominant congenital cataract and anterior segment dysgenesis have similar phenotypic and functional characteristics.Orphanet journal of rare diseases · 2014Article
- Cold-shock-domain protein A (CSDA) contributes posttranscriptionally to gonadotropin-releasing hormone-regulated expression of Egr1 and indirectly to Lhb.Biology of reproduction · 2012Article
- PITX2 AND PITX1 regulate thyrotroph function and response to hypothyroidism.Molecular endocrinology (Baltimore, Md.) · 2011Article
- Pitx1 haploinsufficiency causes clubfoot in humans and a clubfoot-like phenotype in mice.Human molecular genetics · 2011Article
- The estrogen-regulated transcription factor PITX1 coordinates gene-specific regulation by estrogen receptor-alpha in breast cancer cells.Molecular endocrinology (Baltimore, Md.) · 2011Article
- A Pit-1 threonine 220 phosphomimic reduces binding to monomeric DNA sites to inhibit Ras and estrogen stimulation of the prolactin gene promoter.Molecular endocrinology (Baltimore, Md.) · 2010Article
- Genetic regulation of pituitary gland development in human and mouse.Endocrine reviews · 2009Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A novel OTX-related homeodomain transcription factor has been identified on the basis of its ability to interact with the transactivation domain of the pituitary-specific POU domain protein, Pit-1. This factor, referred to as P-OTX (pituitary OTX-related factor), is expressed in primordial Rathke's pouch, oral epithelium, first bronchial arch, duodenum, and hindlimb. In the developing anterior pituitary, it is expressed in all regions from which cells with distinct phenotypes will emerge in the mature gland. P-OTX is able to independently activate and to synergize with Pit-1 on pituitary-specific target gene promoters. Therefore, P-OTX may subserve functions in generating both precursor and specific cell phenotypes in the anterior pituitary gland and in several other organs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.