ArticleProceedings of the National Academy of Sciences of the United States of America1996
Distinct desmocollin isoforms occur in the same desmosomes and show reciprocally graded distributions in bovine nasal epidermis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 100 citations in OpenAlex.
- Desmosomes at a glance.Journal of cell science · 2024Review
- Epidermal stratification requires retromer-mediated desmoglein-1 recycling.Developmental cell · 2022Article
- Desmosomal Cadherins in Health and Disease.Annual review of pathology · 2022Review
- Tutorial: guidance for quantitative confocal microscopy.Nature protocols · 2020Review
- Influence of Vitamin D on Corneal Epithelial Cell Desmosomes and Hemidesmosomes.Investigative ophthalmology & visual science · 2019Article
- Genomic signature of parity in the breast of premenopausal women.Breast cancer research : BCR · 2019Article
- Structural basis of adhesive binding by desmocollins and desmogleins.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Mechanistic basis of desmosome-targeted diseases.Journal of molecular biology · 2013Review
- Desmosomal cadherins in zebrafish epiboly and gastrulation.BMC developmental biology · 2012Article
- Membrane-impermeable cross-linking provides evidence for homophilic, isoform-specific binding of desmosomal cadherins in epithelial cells.The Journal of biological chemistry · 2011Article
- Intercellular junction assembly, dynamics, and homeostasis.Cold Spring Harbor perspectives in biology · 2010Review
- Disruption of desmosome assembly by monovalent human pemphigus vulgaris monoclonal antibodies.The Journal of investigative dermatology · 2009Article
- Differential expression and distribution of epithelial adhesion molecules in non-small cell lung cancer and normal bronchus.Journal of clinical pathology · 2007Article
- Mutant desmocollin-2 causes arrhythmogenic right ventricular cardiomyopathy.American journal of human genetics · 2006Article
- Desmocollin switching in colorectal cancer.British journal of cancer · 2006Article
- Desmosomal cadherin misexpression alters beta-catenin stability and epidermal differentiation.Molecular and cellular biology · 2005Article
- Regulation of desmocollin gene expression in the epidermis: CCAAT/enhancer-binding proteins modulate early and late events in keratinocyte differentiation.The Biochemical journal · 2004Article
- Assessment of splice variant-specific functions of desmocollin 1 in the skin.Molecular and cellular biology · 2004Article
- Altered expression of desmosomal components in high-grade squamous intraepithelial lesions of the cervix.Virchows Archiv : an international journal of pathology · 2003Article
- Defining desmosomal plakophilin-3 interactions.The Journal of cell biology · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adhesive core of the desmosome is composed of cadherin-like glycoproteins of two families, desmocollins and desmogleins. Three isoforms of each are expressed in a tissue-specific and developmentally regulated pattern. In bovine nasal epidermis, the three desmocollin (Dsc) isoforms are expressed in overlapping domains; Dsc3 expression is strongest in the basal layer, while Dsc2 and Dsc1 are strongly expressed in the suprabasal layers. Herein we have investigated whether different isoforms are assembled into the same or distinct desmosomes by performing double immunogold labeling using isoform-specific antibodies directed against Dsc1 and Dsc3. The results show that individual desmosomes harbor both isoforms in regions where their expression territories overlap. Quantification showed that the ratio of the proteins in each desmosome altered gradually from basal to immediately suprabasal and upper suprabasal layers, labeling for Dsc1 increasing and Dsc3 decreasing. Thus desmosomes are constantly modified as cells move up the epidermis, with continuing turnover of the desmosomal glycoproteins. Statistical analysis of the quantitative data showed a possible relationship between the distributions of the two isoforms. This gradual change in desmosomal composition may constitute a vertical adhesive gradient within the epidermis, having important consequences for cell positioning and differentiation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.