ArticleMolecular and cellular biology1996
Unimpaired macrophage differentiation and activation in mice lacking the zinc finger transplantation factor NGFI-A (EGR1).
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 94 citations in OpenAlex.
- Article
- The JNK-EGR1 signaling axis promotes TNF-α-induced endothelial differentiation of human mesenchymal stem cells via VEGFR2 expression.Cell death and differentiation · 2023Article
- Early Growth Response Factor 1 in Aging Hematopoietic Stem Cells and Leukemia.Frontiers in cell and developmental biology · 2022Review
- Microglial P2 Purinergic Receptor and Immunomodulatory Gene Transcripts Vary By Region, Sex, and Age in the Healthy Mouse CNS.Transcriptomics: open access · 2015Article
- Haplotype-specific modulation of a SOX10/CREB response element at the Charcot-Marie-Tooth disease type 4C locus SH3TC2.Human molecular genetics · 2014Article
- Impaired adult myeloid progenitor CMP and GMP cell function in conditional c-myb-knockout mice.Cell cycle (Georgetown, Tex.) · 2012Article
- The nucleosome remodeling and deacetylase chromatin remodeling (NuRD) complex is required for peripheral nerve myelination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Article
- Early growth response 1 (Egr1) regulates cholesterol biosynthetic gene expression.The Journal of biological chemistry · 2011Article
- Reduction of PKCbetaII activity in smooth muscle cells attenuates acute arterial injury.Atherosclerosis · 2010Article
- Hepatic fibrosis is enhanced and accompanied by robust oval cell activation after chronic carbon tetrachloride administration to Egr-1-deficient mice.The American journal of pathology · 2010Article
- Egr-1 is necessary for fibroblast growth factor-2-induced transcriptional activation of the glial cell line-derived neurotrophic factor in murine astrocytes.The Journal of biological chemistry · 2009Article
- Is EGR1 a potential target for prostate cancer therapy?Future oncology (London, England) · 2009Review
- Expression of P2 nucleotide receptors varies with age and sex in murine brain microglia.Journal of neuroinflammation · 2009Article
- Dysregulation of CXCL9 and reduced tumor growth in Egr-1 deficient mice.Journal of hematology & oncology · 2009Article
- Induction of early growth response-1 mediates microglia activation in vitro but is dispensable in vivo.Neuromolecular medicine · 2009Article
- Early growth response genes regulate B cell development, proliferation, and immune response.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Proinflammatory role of leukocyte-derived Egr-1 in the development of murine postoperative ileus.Gastroenterology · 2008Article
- Roles of IL-6-gp130 Signaling in Vascular Inflammation.Current cardiology reviews · 2008Article
- Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The zinc finger protein NGFI-A (also called EGR1, Krox24, or zif268) is a candidate regulator of myeloid cell differentiation. Evidence supporting this hypothesis is twofold. First, NGFI-A antisense oligonucleotides prevent macrophage differentiation in HL-60 and U937 myeloid leukemia cell lines and in normal bone marrow cells. Second, enforced expression of NGFI-A blocks granulocytic differentiation and promotes macrophage differentiation in HL-60 cells and in the hematopoietic progenitor cell line 32D. We sought to determine the effect of NGFI-A deficiency on macrophage differentiation and function in vivo by examining native bone marrow cells from mice homozygous for a disrupted allele of NGFI-A derived from gene-targeted ES cells. Macrophages were observed in peripheral blood and several tissues, indicating that NGFI-A was not required for the formation of a variety of macrophage compartments. No differences in myeloid cell differentiation were observed between wild-type and NGFI-A-/- bone marrow cells cultured in the presence of macrophage, granulocyte-macrophage, or granulocyte colony-stimulating factor (M-CSF, GM-CSF, or G-CSF). Activation of NGFI-A-/- macrophages was comparable to that of wild-type macrophages as determined by nitric oxide production and increased cell surface expression of class II major histocompatibility complex molecules. Moreover, NGFI-A-/- mice showed no increased mortality or bacteria] burden when challenged with Listeria monocytogenes. Together, these results indicate that NGFI-A is not required for macrophage differentiation or activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.