ArticleMolecular and cellular biology1996
A soluble transcription factor, Oct-1, is also found in the insoluble nuclear matrix and possesses silencing activity in its alanine-rich domain.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Genetic associations of type 2 diabetes with islet amyloid polypeptide processing and degrading pathways in asian populations.PloS one · 2013Pooled it
- Long-Distance Repression by Human Silencers: Chromatin Interactions and Phase Separation in Silencers.Cells · 2022Review
- Article
- Protein sequestration at the nuclear periphery as a potential regulatory mechanism in premature aging.The Journal of cell biology · 2018Review
- Article
- Eomesodermin of atlantic salmon: an important regulator of cytolytic gene and interferon gamma expression in spleen lymphocytes.PloS one · 2013Article
- A 43-bp A/T-rich element upstream of the kinesin gene AtKP1 promoter functions as a silencer in Arabidopsis.Plant cell reports · 2009Article
- A common variant associated with dyslexia reduces expression of the KIAA0319 gene.PLoS genetics · 2009Article
- Lamin B1 controls oxidative stress responses via Oct-1.The Journal of cell biology · 2009Article
- Sequence analysis of coding and 3' and 5' flanking regions of the epithelial sodium channel alpha, beta, and gamma genes in Dahl S versus R rats.BMC genetics · 2007Article
- Silencing of Fshr occurs through a conserved, hypersensitive site in the first intron.Molecular endocrinology (Baltimore, Md.) · 2005Article
- Functional interactions with Pit-1 reorganize co-repressor complexes in the living cell nucleus.Journal of cell science · 2005Article
- The HoxC4 homeodomain protein mediates activation of the immunoglobulin heavy chain 3' hs1,2 enhancer in human B cells. Relevance to class switch DNA recombination.The Journal of biological chemistry · 2004Article
- Nuclear factor 1 is required for both hormone-dependent chromatin remodeling and transcriptional activation of the mouse mammary tumor virus promoter.Molecular and cellular biology · 2003Article
- hnRNP U inhibits carboxy-terminal domain phosphorylation by TFIIH and represses RNA polymerase II elongation.Molecular and cellular biology · 1999Article
- Metabolic labeling of woodchuck hepatitis B virus X protein in naturally infected hepatocytes reveals a bimodal half-life and association with the nuclear framework.Journal of virology · 1998Article
- Transcriptional control and the role of silencers in transcriptional regulation in eukaryotes.The Biochemical journal · 1998Review
- Dissociation of Oct-1 from the nuclear peripheral structure induces the cellular aging-associated collagenase gene expression.Molecular biology of the cell · 1997Article
- POU domain transcription factors in embryonic development.Molecular biology reports · 1997Review
- [Molecular-genetic mechanisms of developing the brain based on an embryonic Xenopus model].Molekuliarnaia biologiiaReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expression of the human thyrotropin beta (hTSHbeta) gene is restricted to thyrotrophs, at least in part, by silencing. Using transient-transfection assays, we have localized a silencer element to a region between -128 and -480 bp upstream of the transcription initiation site. The silencing activity was overcome in a thyrotroph-specific manner by an unknown enhancer located in the sequences at -approximately 10000 to -1200 bp. The ubiquitous POU homeodomain protein Oct-1 recognized the A/T-rich silencer element at multiple sites in gel mobility shift assays and in vitro footprinting analyses. The silencing activity of Oct-1 was localized in its C-terminal alanine-rich domain, suggesting that Oct-1 plays a role in silencing of the hTSHbeta promoter. Further, a significant fraction of Oct-1 was shown to be associated with the nuclear matrix, and the hTSHbeta silencer region was tethered to a nuclear matrix of human cells in vivo, suggesting a possible role of the Oct-1-hTSHbeta silencer region interaction in chromatin organization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.