ArticleMolecular and cellular biology1996
Functional interaction between p53, the TATA-binding protein (TBP), andTBP-associated factors in vivo.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 110 citations in OpenAlex.
- On the Role of TATA Boxes and TATA-Binding Protein inPlants (Basel, Switzerland) · 2023Review
- High Throughput miRNA Screening Identifies miR-574-3p Hyperproductive Effect in CHO Cells.Biomolecules · 2021Article
- Simultaneous measurement of p53:Mdm2 and p53:Mdm4 protein-protein interactions in whole cells using fluorescence labelled foci.Scientific reports · 2019Article
- Global re-wiring of p53 transcription regulation by the hepatitis B virus X protein.Molecular oncology · 2016Article
- Activation of p53 transcriptional activity by SMRT: a histone deacetylase 3-independent function of a transcriptional corepressor.Molecular and cellular biology · 2014Article
- Article
- p53 can repress transcription of cell cycle genes through a p21(WAF1/CIP1)-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements.Cell cycle (Georgetown, Tex.) · 2012Article
- p53 regulates Ki-67 promoter activity through p53- and Sp1-dependent manner in HeLa cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2011Article
- The biology of lysine acetylation integrates transcriptional programming and metabolism.Nutrition & metabolism · 2011Article
- One function--multiple mechanisms: the manifold activities of p53 as a transcriptional repressor.Journal of biomedicine & biotechnology · 2011Review
- Transcriptional regulation by p53.Cold Spring Harbor perspectives in biology · 2010Review
- TAF6delta orchestrates an apoptotic transcriptome profile and interacts functionally with p53.BMC molecular biology · 2010Article
- p53 controls hPar1 function and expression.Oncogene · 2008Article
- Article
- TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function.BMC molecular biology · 2008Article
- The contribution of transactivation subdomains 1 and 2 to p53-induced gene expression is heterogeneous but not subdomain-specific.Neoplasia (New York, N.Y.) · 2007Article
- The novel PIAS-like protein hZimp10 is a transcriptional co-activator of the p53 tumor suppressor.Nucleic acids research · 2007Article
- Tumor suppressor p53 regulates heparanase gene expression.Oncogene · 2006Article
- p53 negatively regulates the expression of FAT10, a gene upregulated in various cancers.Oncogene · 2006Article
- Post-transcriptional regulation of thioredoxin by the stress inducible heterogenous ribonucleoprotein A18.Nucleic acids research · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The transcriptional activator p53 is known to interact with components of the general transcription factor TFIID in vitro. To examine the relevance of these associations to transcriptional activation in vivo, plasmids expressing a p53-GAL4 chimera and Drosophila TATA-binding protein (dTBP) were transfected into Drosophila Schneider cells. p53-GAL4 and dTBP displayed a markedly synergistic effect on activated transcription from a GAL4 site-containing reporter that was at least 10-fold greater than observed with other activators tested. A mutant p53 previously shown to be defective in both transcriptional activation in vivo and in binding to TBP-associated factors (TAFs) in vitro, although still capable of binding dTBP, did not cooperate with dTBP, suggesting that TAFs may contribute to this synergy. Providing further support for this possibility, transfected dTBP assembled into rapidly sedimenting complexes and could be immunoprecipitated with anti-TAF antibodies. While overexpression of any of several TAFs did not affect basal transcription, in either the presence or the absence of cotransfected dTBP, overexpression of TAFII230 inhibited transcriptional activation mediated by p53-GAL4 as well as by GAL4-VP16 and Sp1. Overexpression of TAFII40 and TAFII60 also inhibited activation by p53-GAL4 but had negligible effects on activation by GAL4-VP16 and Sp1, while TAFII110 did not affect any of the activators. TAF-mediated inhibition of activated transcription could be rescued by high levels of exogenous dTBP, which also restored full synergy. These data demonstrate for the first time that functional interactions can occur in vivo between TBP, TAFs, and p53.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.