ArticleMolecular and cellular biology1996
Transcriptional induction of the alpha-1 acid glycoprotein (AGP) gene by synergistic interaction of two alternative activator forms of AGP/enhancer-binding protein (C/EBP beta) and NF-kappaB or Nopp140.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 62 citations in OpenAlex.
- Potential of acute phase proteins as predictor of postpartum uterine infections during transition period and its regulatory mechanism in dairy cattle.Veterinary world · 2016Review
- Mutation of a Nopp140 gene dao-5 alters rDNA transcription and increases germ cell apoptosis in C. elegans.Cell death & disease · 2014Article
- Secretory phospholipase A2, group IIA is a novel serum amyloid A target gene: activation of smooth muscle cell expression by an interleukin-1 receptor-independent mechanism.The Journal of biological chemistry · 2010Article
- CCAAT/enhancer-binding protein beta: its role in breast cancer and associations with receptor tyrosine kinases.Expert reviews in molecular medicine · 2009Review
- CCAAT/enhancer-binding proteins and the pathogenesis of retrovirus infection.Future microbiology · 2009Review
- The interferon signaling network and transcription factor C/EBP-beta.Cellular & molecular immunology · 2007Review
- C/EBPalpha regulates generation of C/EBPbeta isoforms through activation of specific proteolytic cleavage.Molecular and cellular biology · 1999Article
- C/EBPalpha is critical for the neonatal acute-phase response to inflammation.Molecular and cellular biology · 1998Article
- A three-dimensional collagen lattice activates NF-kappaB in human fibroblasts: role in integrin alpha2 gene expression and tissue remodeling.The Journal of cell biology · 1998Article
- Identification and characterization of a nucleolar phosphoprotein, Nopp140, as a transcription factor.Molecular and cellular biology · 1997Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alpha-1 acid glycoprotein/enhancer-binding protein (AGP/EBP) (C/EBPbeta), a member of the C/EBP family, is one of the key transcription factors responsible for the induction of a wide array of genes, some of which are expressed during the acute-phase response. Both activator and repressor were shown to be encoded by the intronless agp/ebp or its rat and human homologs, which contain a common bZIP domain at their C-terminal regions. Expression of the AGP gene (agp) is regulated by AGP/EBP in liver during the acute-phase response. However, the molecular mechanism for this regulation is poorly understood. The experiments reported here demonstrate that two activator forms of AGP/EBP, one of which has an additional 21 amino acids at its N-terminal region, are expressed in liver as well as in a number of cell lines. We have also demonstrated that NF-kappaB and a phosphoprotein of 140 kDa, Nopp140, interact with different AGP/EBP activators synergistically, which results in induction of the agp gene in an AGP/EBP-binding-motif-dependent manner. Furthermore, extracellular stimuli that are known to be NF-kappaB inducers can selectively activate the agp gene by cooperating with one of the two activator forms of AGP/EBP. The physiological significance of differential regulation for the function of two activator forms of AGP/EBP through selective interaction with different transcription factors is discussed.
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