ArticleBehavior genetics1996
Molecular genetics of psychopathologies: a search for simple answers to complex problems.
Article in Behavior genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Association between serotonin transporter polymorphisms (5-HTTLPR) and the MADRS Dysphoria, Retardation, and Vegetative Subscale scores in the treatment of depression.Neuropsychiatric disease and treatment · 2017Article
- A cluster model of temperament as an indicator of antidepressant response and symptom severity in major depression.Psychiatry investigation · 2014Article
- Annual research review: embracing not erasing contextual variability in children's behavior--theory and utility in the selection and use of methods and informants in developmental psychopathology.Journal of child psychology and psychiatry, and allied disciplines · 2012Review
- Automated classification of fMRI during cognitive control identifies more severely disorganized subjects with schizophrenia.Schizophrenia research · 2012Article
- The diagnostic concept of schizophrenia: its history, evolution, and future prospects.Dialogues in clinical neuroscience · 2010Article
- The DSM-V initiative "deconstructing psychosis" in the context of Kraepelin's concept on nosology.European archives of psychiatry and clinical neuroscience · 2008Review
- Subtyping schizophrenia: implications for genetic research.Molecular psychiatry · 2006Review
- Linkage analysis of candidate regions using a composite neurocognitive phenotype correlated with schizophrenia.Molecular psychiatry · 2003Article
- Dopamine receptor D2 Ser/Cys 311 variant is associated with delusion and disorganization symptomatology in major psychoses.Molecular psychiatry · 2000Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular genetics is helping define the contribution of genetic involvement in behavioral disorders. At this time, however, a severely limiting factor for DNA linkage studies of these disorders remains the definition of the phenotype. An example of this is found in the group of studies examining linkage of schizophrenia to the 5q location. Although various broad clinical interpretations of the schizophrenia phenotype were used to test for linkage, all but one study reported findings negative for linkage of schizophrenia to the 5q area. We offer a strategy based on family studies using segregation data of behavioral subtypes. We apply this strategy using molecular genetic technology to our study of psychopathology in patients. This approach offers the possibility of a clearer definition of the phenotype and is suggested for use in both linkage and association studies of neuropsychiatric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.