Application of antisense DNA method for the study of molecular bases of brain function and behavior.

S Ogawa, D W Pfaff

Abstract readReview

In one paragraph

Review in Behavior genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

1.8field-weighted citation impact, top 15% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 38 citations in OpenAlex.

Progress in genetic studies of pain and analgesia.Annual review of pharmacology and toxicology · 2009
Review
Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

S OgawaLaboratory of Neurobiology and Behavior, Rockefeller University, New York, New York 10021, USA.

D W Pfaff

Rockefeller University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The antisense DNA method has been used successfully not only in vitro but also with in vivo systems to block effectively the expression of specific genes. An increasing number of studies have shown that antisense DNA administered directly into the brain can modify various kinds of behaviors. These findings strongly suggest that the antisense DNA method can be widely used as a powerful tool for the study of the molecular bases of behavior. In addition to traditional methods of behavioral genetics, the antisense DNA method may provide a new approach for the study of the effects of gene in behavioral function. In this article, we review recent studies reporting in vivo effects of antisense DNA on brain function and behavior.

Indexed as

DNA, AntisenseGenetics, BehavioralAnimalsAppetitive BehaviorBehavior, AnimalBrainBrain MappingGene ExpressionHumansMiceMotor ActivityNeurosecretory SystemsPain ThresholdProto-Oncogene Proteins c-fosRatsReceptors, ProgesteroneDNA, AntisenseProto-Oncogene Proteins c-fosReceptors, ProgesteroneRNA, Messenger

Identifiers

PMID8754251

DOI10.1007/BF02359384

OpenAlexW2045981407

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.