ArticleInfection and immunity1996
Anti-interleukin-4 modulation of the Th2 polarized response to the parasitic nematode Brugia pahangi.
Article in Infection and immunity, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- Evaluation of viremia, proviral load and cytokine profile in naturally feline immunodeficiency virus infected cats treated with two different protocols of recombinant feline interferon omega.Research in veterinary science · 2015Article
- Article
- Release of Small RNA-containing Exosome-like Vesicles from the Human Filarial Parasite Brugia malayi.PLoS neglected tropical diseases · 2015Article
- Article
- Role of helminths in regulating mucosal inflammation.Springer seminars in immunopathology · 2005Review
- Regulatory T cells modulate Th2 responses induced by Brugia pahangi third-stage larvae.Infection and immunity · 2005Article
- Interleukin-10 (IL-10) counterregulates IL-4-dependent effector mechanisms in Murine Filariasis.Infection and immunity · 2004Article
- Nitric oxide limits the expansion of antigen-specific T cells in mice infected with the microfilariae of Brugia pahangi.Infection and immunity · 2002Article
- Infection outcome and cytokine gene expression in Brugia pahangi- infected gerbils (Meriones unguiculatus) sensitized with Brucella abortus.Infection and immunity · 2002Article
- Interleukin-4 receptor-Stat6 signaling in murine infections with a tissue-dwelling nematode parasite.Infection and immunity · 2001Article
- NO contributes to proliferative suppression in a murine model of filariasis.Infection and immunity · 2000Article
- Interleukin-10 and antigen-presenting cells actively suppress Th1 cells in BALB/c mice infected with the filarial parasite Brugia pahangi.Infection and immunity · 1999Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Lymphatic filariasis is a chronic disease characterized by a pronounced Th2 bias in the immune response and impaired antigen (Ag)-specific Th1 responses. We have used a mouse model of filariasis to investigate the role of the infective form (the third-stage larvae [L3]) in modulating the immune response. Subcutaneous infection of BALB/c mice with L3 of Brugia pahangi has a profound effect on Th cell function. By day 12 post-infection, spleen cells from these mice exhibited a dramatic reduction in concanavalin A-driven proliferation and interleukin-2 (IL-2) and gamma interferon (IFN-gamma) secretion in comparison with uninfected controls. However, exposure to L3 did not render the mice completely unresponsive; these animals mounted a strong Th2 response to the parasite, characterized by elevated levels of IL-4, IL-5, and IL-10 and parasite-specific serum immunoglobulin G (IgG), IgG1, and IgE. Treatment of spleen cells from L3-infected mice with neutralizing anti-IL-4 or recombinant IL-2 resulted in a dramatic increase in concanavalin A-induced proliferation and IL-2 and IFN-gamma production. Despite their defective polyclonal Th1 response, cells from L3 infected mice proliferated when stimulated with Ag, and this response was blocked by anti-IL-4. However, anti-IL-4 treatment failed to induce Ag-specific IL-2 or IFN-gamma production, indicating that B.pahangi-primed Th1 cells do not appear to be present or are still unable to respond even in the absence of IL-4.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.