ArticleAmerican journal of human genetics1996
Genome scanning for linkage: an overview.
Article in American journal of human genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Finding disease genes: a fast and flexible approach for analyzing high-throughput data.European journal of human genetics : EJHG · 2011Article
- Computer simulation is an undervalued tool for genetic analysis: a historical view and presentation of SHIMSHON--a Web-based genetic simulation package.Human heredity · 2011Article
- Statistical Analysis in Genetic Studies of Mental Illnesses.Statistical science : a review journal of the Institute of Mathematical Statistics · 2011Article
- Estimation of genotype relative risks from pedigree data by retrospective likelihoods.Genetic epidemiology · 2010Article
- Robust age at onset linkage analysis in nuclear families.Human heredity · 2010Article
- Genomic similarity and kernel methods I: advancements by building on mathematical and statistical foundations.Human heredity · 2010Review
- A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.Journal of diabetes science and technology · 2009Article
- Design considerations in a sib-pair study of linkage for susceptibility loci in cancer.BMC medical genetics · 2008Article
- A unified discussion on the concept of score functions used in the context of nonparametric linkage analysis.Bioinformatics and biology insights · 2008Article
- Weighting affected sib pairs by marker informativity.American journal of human genetics · 2005Article
- Inherent bias toward the null hypothesis in conventional multipoint nonparametric linkage analysis.American journal of human genetics · 2004Article
- Genetic linkage analysis of a dichotomous trait incorporating a tightly linked quantitative trait in affected sib pairs.American journal of human genetics · 2003Article
- A statistical method for identification of polymorphisms that explain a linkage result.American journal of human genetics · 2002Article
- All LODs are not created equal.American journal of human genetics · 2000Article
- Linkage analysis in the presence of errors IV: joint pseudomarker analysis of linkage and/or linkage disequilibrium on a mixture of pedigrees and singletons when the mode of inheritance cannot be accurately specified.American journal of human genetics · 2000Article
- Linkage detection adaptive to linkage disequilibrium: the disequilibrium maximum-likelihood-binomial test for affected-sibship data.American journal of human genetics · 1999Article
- Assessment of linkage disequilibrium by the decay of haplotype sharing, with application to fine-scale genetic mapping.American journal of human genetics · 1999Article
- Mapping of complex traits by single-nucleotide polymorphisms.American journal of human genetics · 1998Article
- Simple, robust linkage tests for affected sibs.American journal of human genetics · 1998Article
- Allele-sharing models: LOD scores and accurate linkage tests.American journal of human genetics · 1997Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Several different methods for linkage analysis are shown to arise from a single likelihood function L for the observed allele-sharing data at multiple markers in a chromosomal region. These include classical parametric lod score methods, nonparametric or "model-free" affected pedigree-member (APM) methods, and the Gaussian process method. Setting the methods in the context of the likelihood function L clarifies their underlying assumptions. A test statistic derived from L, the efficient score statistic, is introduced. It is asymptotically equivalent to the lod score, but it can be easier to compute when the penetrances and frequencies of alleles of the trait gene are not known. APM test statistics and the Gaussian lod score are shown to be special cases of efficient score statistics. This unified framework facilitates exploration of a range of models for the effects of a putative trait-predisposing gene, and it facilitates sensitivity analyses to examine the consequences of model misspecification.
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8751872PMC1914900What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.