ArticleAmerican journal of human genetics1996
Localization of the familial Mediterranean fever gene (FMF) to a 250-kb interval in non-Ashkenazi Jewish founder haplotypes. The French FMF Consortium.
Article in American journal of human genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 10 citations in OpenAlex.
- Genotype Mutations in Palestinian Children with Familial Mediterranean Fever: Clinical Profile, and Response to Colchicine Treatment: A Retrospective Cohort Study.Mediterranean journal of rheumatology · 2023Article
- Genotype Mutations in Egyptian Children with Familial Mediterranean Fever: Clinical Profile, and Response to Colchicine.Mediterranean journal of rheumatology · 2020Article
- Dermatologic and Dermatopathologic Features of Monogenic Autoinflammatory Diseases.Frontiers in immunology · 2019Review
- Dermatologic Manifestations of Monogenic Autoinflammatory Diseases.Dermatologic clinics · 2017Review
- Gene hunting in autoinflammation.Clinical and translational allergy · 2013Article
- Mediterranean fever (MEFV) gene mutation frequency is not increased in adults with rheumatic heart disease.Clinical rheumatology · 2011Article
- Characterization of new mutations in the 5'-flanking region of the familial Mediterranean fever gene.Genes and immunity · 2009Article
- Construction of an approximately 700-kb transcript map around the familial Mediterranean fever locus on human chromosome 16p13.3.Genome research · 1998Article
- Genetic linkage study of familial Mediterranean fever (FMF) to 16p13.3 and evidence for genetic heterogeneity in the Turkish population.Journal of medical genetics · 1997Article
- Genotypic diagnosis of familial Mediterranean fever (FMF) using new microsatellite markers: example of two extensive non-Ashkenazi Jewish pedigrees.Journal of medical genetics · 1997Article
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Abstract
Chromosome 16p13.3 harbors a gene (MEF) associated with familial Mediterranean fever (FMF), a recessive disease very common in populations of Mediterranean ancestry. In the course of positional cloning of MEF, we genotyped 26 non-Ashkenazi Jewish FMF pedigrees (310 meioses) with 15 microsatellite markers, most of which were recently developed by Généthon. Identification of recombination events in the haplotypes allowed narrowing of the MEF interval to a region between D16S3124 (telomeric) and D16S475 (centromeric). Two markers, D16S3070 and D16S3275, a microsatellite marker isolated from a YAC that also contains D16S3070, showed no recombination with the disease. Linkage disequilibrium and haplotype analysis highlighted the existence of a founder haplotype in our population. The core ancestral alleles were present in 71% of MEF-bearing chromosomes at loci D16S3070 and D16S3275. Furthermore, identification of historical crossing-over events in these pedigrees indicated that MEF is located between these two loci, which are both contained in a 250-kb genomic fragment.
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8751861PMC1914916W4300774784What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.