ArticleJournal of molecular medicine (Berlin, Germany)1995
Messenger RNA expression for a TSH receptor variant in the thymus of a two-year-old child.
Article in Journal of molecular medicine (Berlin, Germany), 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 37 citations in OpenAlex.
- History of the Thymus: From a Vestigial Organ to the Programming of Immunological Self-Tolerance.Advances in experimental medicine and biology · 2025Review
- Atypical pituitary hormone-target tissue axis.Frontiers of medicine · 2023Review
- The thymus and the science of self.Seminars in immunopathology · 2021Review
- The presentation of neuroendocrine self-peptides in the thymus: an essential event for individual life and vertebrate survival.Annals of the New York Academy of Sciences · 2019Review
- Beta-Arrestin 1 Mediates Liver Thyrotropin Regulation of Cholesterol Conversion Metabolism via the Akt-Dependent Pathway.International journal of endocrinology · 2018Article
- Thyroid-Related Protein Expression in the Human Thymus.International journal of endocrinology · 2017Article
- TSH inhibits SERCA2a and the PKA/PLN pathway in rat cardiomyocytes.Oncotarget · 2016Article
- Functional thyrotropin receptor expression in the ventricle and the effects on ventricular BNP secretion.Endocrine · 2014Article
- Programming of neuroendocrine self in the thymus and its defect in the development of neuroendocrine autoimmunity.Frontiers in neuroscience · 2013Review
- Functional expression of the thyrotropin receptor in C cells: new insights into their involvement in the hypothalamic-pituitary-thyroid axis.Journal of anatomy · 2009Article
- Presence of thyrotropin receptor in hepatocytes: not a case of illegitimate transcription.Journal of cellular and molecular medicineArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We recently described the presence of a thyroid-stimulating hormone receptor (TSH-R) variant in orbital tissues. Although the presence of this TSH-R variant could provide the antigenic link between the thyroid and the orbit in Graves' disease and thyroid-associated ophthalmopathy (TAO), the etiopathophysiological significance of this finding remains to be elucidated. Graves' disease and TAO are autoimmune diseases which are likely to be caused by a breakdown of tolerance. We therefore investigated the presence of this variant TSH-R transcript in human thymus. Using primers specific for this variant in reverse polymerase chain reaction (PCR) experiments, Southern blotting, and sequencing of the PCR products we demonstrate the presence of this transcript in RNA extracted from normal human thymus of a 2-year-old child. We were also able to amplify this variant TSH-R transcript from a normal human thyroid cDNA library, but not from an epithelial thymus library. The presence of the variant TSH-R transcript in RNA prepared from normal human thymus suggests that induction of immunological tolerance against this variant TSH-R transcript in the thymus is possible. A lack of tolerance induction for this variant TSH-R transcript could provide an explanation for a possible antigenic link between Graves' disease and TAO.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.