ArticleBreast cancer research and treatment1996
Correlation of growth fraction by Ki-67 and proliferating cell nuclear antigen (PCNA) immunohistochemistry with histopathological parameters and prognosis in primary breast carcinomas.
Article in Breast cancer research and treatment, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Ki-67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12,155 patients.British journal of cancer · 2007Pooled it
- Envisioning Clinical Management of Breast Cancer: a Comprehensive Review.Current drug discovery technologies · 2025Review
- Ki-67 Index and Its Correlation with Clinical and Pathological Variables in Breast Cancer.Indian journal of surgical oncology · 2023Article
- Targeting Non-Oncogene Addiction for Cancer Therapy.Biomolecules · 2021Review
- Prognostic and Clinicopathological Correlations of Cell Cycle Marker Expressions before and after the Primary Systemic Therapy of Breast Cancer.Pathology oncology research : POR · 2020Article
- Ki-67 is a prognostic parameter in breast cancer patients: results of a large population-based cohort of a cancer registry.Breast cancer research and treatment · 2013Article
- Targeting tyrosine phosphorylation of PCNA inhibits prostate cancer growth.Molecular cancer therapeutics · 2011Article
- Expression of cell cycle proteins in male breast carcinoma.World journal of surgical oncology · 2010Article
- Role of cytologic grading in prognostication of invasive breast carcinoma.Journal of cytology · 2009Article
- An overview of prognostic factors for long-term survivors of breast cancer.Breast cancer research and treatment · 2008Review
- Grading invasive ductal carcinoma of the breast: advantages of using automated proliferation index instead of mitotic count.Virchows Archiv : an international journal of pathology · 2007Article
- Prognostic factors in node-negative breast cancer: a review of studies with sample size more than 200 and follow-up more than 5 years.Annals of surgery · 2002Review
- Prognostic significance of MIB1-determined proliferative activities in intraductal components and invasive foci associated with invasive ductal breast carcinoma.British journal of cancer · 1999Article
- MIB1-determined proliferative activity in intraductal components and prognosis of invasive ductal breast carcinoma.Japanese journal of cancer research : Gann · 1997Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The immunoreactivity for Ki-67 and PCNA was investigated in 487 patients with primary breast carcinomas using MIB-1 (Immunotech, France) and PC-10 (DAKO, Denmark) as primary antibodies. Formalin-fixed and paraffin-embedded tissue sections were used. The immunoreactivity for Ki-67 and PCNA was found to be independent of the length of fixation if the sections were pretreated in a microwave oven in citrate buffer and distilled water, respectively. The immunostaining was evaluated semiquantitatively. High Ki-67 score (more than 1% positive tumour cells) and PCNA over-expression (more than 25% positive tumour cells) were correlated with clinicopathological parameters such as large tumour size, high histological grade (poor differentiation), and absence of steroid hormone receptors, which are parameters of an aggressive phenotype of the tumour. In univariate analysis of survival data, both Ki-67 and PCNA were parameters of a poor overall survival in both lymph node-positive and -negative patients. In multivariate anlaysis using a Cox model stratified by nodal status, Ki-67 and PCNA failed to be of prognostic significance whereas classical histopathological parameters such as tumour size and histological grade turned out to be of independent prognostic significance in both lymph node-positive and -negative patients, while progesterone receptors were of independent prognostic significance only in lymph node-positive patients.
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