ArticleMammalian genome : official journal of the International Mammalian Genome Society1995
Congenic strains reveal effects of the epilepsy quantitative trait locus, El2, separate from other El loci.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 51 citations in OpenAlex.
- The relevance of inter- and intrastrain differences in mice and rats and their implications for models of seizures and epilepsy.Epilepsy & behavior : E&B · 2017Review
- Confirmation of an epilepsy modifier locus on mouse chromosome 11 and candidate gene analysis by RNA-Seq.Genes, brain, and behavior · 2012Article
- Canine epilepsy genetics.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Review
- Mapping a barbiturate withdrawal locus to a 0.44 Mb interval and analysis of a novel null mutant identify a role for Kcnj9 (GIRK3) in withdrawal from pentobarbital, zolpidem, and ethanol.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Management of multifactorial idiopathic epilepsy in EL mice with caloric restriction and the ketogenic diet: role of glucose and ketone bodies.Nutrition & metabolism · 2004Article
- A major effect QTL determined by multiple genes in epileptic EL mice.Genome research · 2000Article
- Genetic dissection of X-linked interspecific hybrid placental dysplasia in congenic mouse strains.Genetics · 1999Article
- Mapping quantitative trait loci for seizure response to a GABAA receptor inverse agonist in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Construction of a double congenic strain to prove an epistatic interaction on blood pressure between rat chromosomes 2 and 10.The Journal of clinical investigation · 1998Article
- Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q.The Journal of clinical investigation · 1997Article
- Genotype selection to rapidly breed congenic strains.Genetics · 1997Article
- Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Interval-specific congenic strains (ISCS): an experimental design for mapping a QTL into a 1-centimorgan interval.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- New seizure frequency QTL and the complex genetics of epilepsy in EL mice.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Congenic mouse strains made by transferring epilepsy predisposing alleles El1, El2, and El3 from the EL/Suz strain to the ABP/Le recipient were tested for seizure frequency following gentle rhythmic stimulation. Mice homozygous for El2, but not El1 or El3, experienced seizures much more frequently than ABP controls, while respective El1 homozygotes and El2 heterozygotes had only a modest increase over ABP, and El3 homozygotes showed no increase. Association between marker genotypes and seizure frequency in small intra-strain crosses showed that the phenotypic effects of El2 map to the selected interval, and that segregation of El2 accounts for virtually all genetic effects. However, in separating El2 from other EL susceptibility alleles, the seizure frequency phenotype was weaker and less heritable than in crosses between parental strains. These results confirm El2 as an important QTL and show that it has significant phenotypic effects in the absence of other EL-derived alleles, including El1. In addition, the present localization of El2 on Chr 2 suggests several potential candidate genes for El2, including the beta subunit of phospholipase-C. The approach to dissecting complex traits by making congenic strains for individual QTL is discussed.
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