ArticleMammalian genome : official journal of the International Mammalian Genome Society1995
New seizure frequency QTL and the complex genetics of epilepsy in EL mice.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 78 citations in OpenAlex.
- Early life phenobarbital exposure dysregulates the hippocampal transcriptome.Frontiers in pharmacology · 2024Article
- The relevance of inter- and intrastrain differences in mice and rats and their implications for models of seizures and epilepsy.Epilepsy & behavior : E&B · 2017Review
- Canine epilepsy genetics.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Review
- Dissociation of seizure traits in inbred strains of mice using the flurothyl kindling model of epileptogenesis.Experimental neurology · 2009Article
- Further studies on using multiple-cross mapping (MCM) to map quantitative trait loci.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- Genetic modifiers affecting severity of epilepsy caused by mutation of sodium channel Scn2a.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
- Effect of YM928, a novel AMPA receptor antagonist, on seizures in EL mice and kainate-induced seizures in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2004Article
- A major effect QTL determined by multiple genes in epileptic EL mice.Genome research · 2000Article
- Mapping loci for pentylenetetrazol-induced seizure susceptibility in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Mapping quantitative trait loci for seizure response to a GABAA receptor inverse agonist in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Mapping murine loci for seizure response to kainic acid.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- Congenic strains reveal effects of the epilepsy quantitative trait locus, El2, separate from other El loci.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
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6 authors at 2 institutions in 1 country.
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Abstract
EL/Suz (EL) mice experience recurrent seizures that are similar to common partial complex epilepsy in humans. In the mice, seizures occur naturally at 90-100 days of age, but can be induced in younger mice and analyzed as a semi-quantitative trait after gentle rhythmic stimulation. A previous genetic mapping study of EL backcrosses to the strains ABP/LeJ or DBA/2J showed two quantitative trait loci (QTL) with large effects on seizure frequency (El1, Chr 9; El2, Chr 2) and implied the existence of other QTL with lesser effects. To further the understanding of EL-derived seizure alleles, we examined intercross progeny of EL and the strains ABP/LeJ and DDY/Jcl, and also a backcross of (EL x DDY)F1 hybrids to DDY. A new large-effect seizure frequency QTL was found (El5, Chr 14), a more minor QTL confirmed (El3, Chr 10), and two additional QTL proposed (El4, Chr 9; El6, Chr 11). The serotonin receptor gene, Htr2a, maps near and is a candidate for El5, and linkages of other serotonin receptor genes to seizure frequency QTL are noted. In addition, a strong gender effect was revealed, and epistasis was found between Chr 9 and Chr 14 markers. Despite this progress, however, our results revealed a more complex determinism of epilepsy in EL mice than previously described. In particular, no single El locus or pair was essential for frequent seizures, as QTL with large effects, such as El5, El2, and El1, were highly dependent on genetic context. Our studies highlight the importance of gene interaction in some complex mammalian traits defined by natural variation.
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