ArticleJournal of bioenergetics and biomembranes1995
Ehrlich cell plasma membrane redox system is modulated through signal transduction pathways involving cGMP and Ca2+ as second messengers.
Article in Journal of bioenergetics and biomembranes, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Glucose-dependent trans-plasma membrane electron transport and p70Redox biology · 2019Article
- Measuring Trans-Plasma Membrane Electron Transport by C2C12 Myotubes.Journal of visualized experiments : JoVE · 2018Article
- Homocysteine is a potent modulator of plasma membrane electron transport systems.Journal of bioenergetics and biomembranes · 2008Article
- Plasma membrane redox and control of sirtuin.Age (Dordrecht, Netherlands) · 2005Article
- The effect of differentiation on the brush border membrane ferric reductase activity in Caco-2 cells.In vitro cellular & developmental biology. Animal · 1998Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ehrlich cell plasma membrane ferricyanide reductase activity increased in the presence of mastoparan, a generic activator of G proteins, using either whole cells or isolated plasma membrane-fractions. Agents that increase intracellular cAMP also increased the rate of ferricyanide reduction by Ehrlich cells. For the first time, evidence is shown on a modulation of plasma membrane redox system by cGMP. In fact, permeant analogs of cGMP, dibutyryl cGMP, and 8-bromo-cGMP increased the rate of ferricyanide reduction by the Ehrlich cell plasma membrane redox system. Furthermore, specific inhibition of cGMP-phosphodiesterases by dipyridamole was also accompanied by an enhancement in the rate of ferricyanide reduction. On the other hand, treatments expected to increase cytoplasmic Ca2+ concentrations were accompanied by a remarkable stimulation of the reductase activity. Taking all these data together, it seems that the Ehrlich cell plasma membrane redox system is under a multiple and complex regulation by different signal transduction pathways involving G proteins, cyclic nucleotides, and Ca2+ ions.
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