ReviewJournal of the Royal College of Physicians of London
Senescence, cancer and 'endogenous parasites': a salutogenic hypothesis.
Review in Journal of the Royal College of Physicians of London. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Validity of Antonovsky's sense of coherence scale: a systematic review.Journal of epidemiology and community health · 2005Pooled it
- Natural Selection in Cancer Biology: From Molecular Snowflakes to Trait Hallmarks.Cold Spring Harbor perspectives in medicine · 2017Review
- Animal cell differentiation patterns suppress somatic evolution.PLoS computational biology · 2007Article
- Radiation and mortality of workers at Oak Ridge National Laboratory: positive associations for doses received at older ages.Environmental health perspectives · 1999Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The integrity and health of an organism can be considered as a state actively imposed by specialised 'salutogenic' mechanisms (immune, endocrine, paracrine etc) on an innate tendency towards internal conflict. One major source of internal conflict arises from the operation of natural selection upon replicating sub-organismal components such as cells, organelles and gene sequences. From this perspective cancer is seen not as a pathological process arising in a healthy organism but as caused by the capacity of replicating cells to evolve 'selfish' adaptations and elude the finite repertoire of integrative mechanisms. Cancer can therefore be regarded as one instance of a more general tendency towards senescence due to the failure of salutogenesis and accumulation of endogenous parasites. This may provide a new and potentially fruitful approach to framing, analysing and understanding the aetiology of the degenerative diseases of senescence.
Indexed as
Identifiers
8745355PMC5401376W2410431515What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.