ArticleBiophysical journal1996
Ion channels from synaptic vesicle membrane fragments reconstituted into lipid bilayers.
Article in Biophysical journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 36 citations in OpenAlex.
- Drunken Membranes: Short-Chain Alcohols Alter Fusion of Liposomes to Planar Lipid Bilayers.Biophysical journal · 2017Article
- Cellular functions of transient receptor potential channels.The international journal of biochemistry & cell biology · 2010Review
- Porosome: the secretory portal in cells.Biochemistry · 2009Review
- Control of neurotransmitter release by an internal gel matrix in synaptic vesicles.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- The synaptic vesicle protein synaptophysin: purification and characterization of its channel activity.Biophysical journal · 2002Article
- SNAREs in opposing bilayers interact in a circular array to form conducting pores.Biophysical journal · 2002Article
- Ca(2+)-regulated, neurosecretory granule channel involved in release from neurohypophysial terminals.The Journal of physiology · 2002Article
- Multitude of ion channels in the regulation of transmitter release.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1999Review
- ATP-sensitive anion channel from rat brain synaptosomal membranes incorporated into planar lipid bilayers.Biophysical journal · 1997Article
- Phospholipase A2 action on planar lipid bilayers generates a small, transitory current that is voltage independent.Biophysical journal · 1997Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cholinergic synaptic vesicles were isolated from the electric organ of Torpedo californica. Vesicle membrane proteins were reconstituted into planar lipid bilayers by the nystatin/ergosterol fusion technique. After fusion, a variety of ion channels were observed. Here we identify four channels and describe two of them in detail. The two channels share a conductance of 13 pS. The first is anion selective and strongly voltage dependent, with a 50% open probability at membrane potentials of -15 mV. The second channel is slightly cation selective and voltage independent. It has a high open probability and a subconductance state. A third channel has a conductance of 4-7 pS, similar to the subconductance state of the second channel. This channel is fairly nonselective and has gating kinetics different from those of the cation channel. Finally, an approximately 10-pS, slightly cation selective channel was also observed. The data indicate that there are one or two copies of each of the above channels in every synaptic vesicle, for a total of six channels per vesicle. These observations confirm the existence of ion channels in synaptic vesicle membranes. It is hypothesized that these channels are involved in vesicle recycling and filling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.