ArticleBiophysical journal1996
A developmental model for generating frequency maps in the reptilian and avian cochleas.
Article in Biophysical journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 39 citations in OpenAlex.
- A circuit for detection of interaural time differences in the nucleus laminaris of turtles.The Journal of experimental biology · 2017Article
- Dynamic compensation mechanism gives rise to period and duty-cycle level sets in oscillatory neuronal models.Journal of neurophysiology · 2016Article
- Hair cell force generation does not amplify or tune vibrations within the chicken basilar papilla.Nature communications · 2016Article
- Article
- Sharp Ca²⁺ nanodomains beneath the ribbon promote highly synchronous multivesicular release at hair cell synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Differential regulation of action potentials by inactivating and noninactivating BK channels in rat adrenal chromaffin cells.Biophysical journal · 2009Article
- Variation in large-conductance, calcium-activated potassium channels from hair cells along the chicken basilar papilla.The Journal of physiology · 2003Article
- Topological and developmental gradients of calbindin expression in the chick's inner ear.Journal of the Association for Research in Otolaryngology : JARO · 2002Article
- Modeling hair cell tuning by expression gradients of potassium channel beta subunits.Biophysical journal · 2002Article
- Direct measurement of single-channel Ca(2+) currents in bullfrog hair cells reveals two distinct channel subtypes.The Journal of physiology · 2001Article
- Pituitary control of BK potassium channel function and intrinsic firing properties of adrenal chromaffin cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Coregulation of voltage-dependent kinetics of Na(+) and K(+) currents in electric organ.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Tonotopic variations of calcium signalling in turtle auditory hair cells.The Journal of physiology · 2000Article
- beta subunits modulate alternatively spliced, large conductance, calcium-activated potassium channels of avian hair cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- The role of Ca2+-activated K+ channel spliced variants in the tonotopic organization of the turtle cochlea.The Journal of physiology · 1999Article
- The endogenous calcium buffer and the time course of transducer adaptation in auditory hair cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Identification of Ca(2+)-activated K+ channel splice variants and their distribution in the turtle cochlea.Proceedings. Biological sciences · 1998Article
- Inactivating BK channels in rat chromaffin cells may arise from heteromultimeric assembly of distinct inactivation-competent and noninactivating subunits.Biophysical journal · 1998Article
- Release sites and calcium channels in hair cells of the chick's cochlea.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- A theoretical study of calcium microdomains in turtle hair cells.Biophysical journal · 1996Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Hair cells in the turtle cochlea are frequency-tuned by a mechanism involving the combined activation of voltage-sensitive Ca2+ channels and Ca(2+)-activated K+ (KCa) channels. The main determinants of a hair cell's characteristic frequency (Fo) are the KCa channels' density and kinetics, both of which change systematically with location in the cochlea in conjunction with the observed frequency map. We have developed a model based on the differential expression of two KCa channel subunits, which when accompanied by concurrent changes in other properties (e.g., density of Ca2+ channels and inwardly rectifying K+ channels), will generate sharp tuning at frequencies from 40 to 600 Hz. The kinetic properties of the two subunits were derived from previous single-channel analysis, and it was assumed that the subunits (A and B) combine to form five species of tetrameric channel (A4, A3B, A2B2, AB3, and B4) with intermediate kinetics and overlapping distribution. Expression of KCa and other channels was assumed to be regulated by diffusional gradients in either one or two chemicals. The results are consistent with both current- and voltage-clamp data on turtle hair cells, and they show that five channel species are sufficient to produce smooth changes in both Fo and kinetics of the macroscopic KCa current. Other schemes for varying KCa channel kinetics are examined, including one that allows extension of the model to the chick cochlea to produce hair cells with Fo's from 130 to 4000 Hz. A necessary assumption in all models is a gradient in the values of the parameters identified with the cell's cytoplasmic Ca2+ buffer.
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