ArticleMolecular biology of the cell1996
Inositol transport in Saccharomyces cerevisiae is regulated by transcriptional and degradative endocytic mechanisms during the growth cycle that are distinct from inositol-induced regulation.
Article in Molecular biology of the cell, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 33 citations in OpenAlex.
- Metabolic engineering of Saccharomyces cerevisiae for efficient production of glucaric acid at high titer.Microbial cell factories · 2018Article
- Insulin-Sensitizers, Polycystic Ovary Syndrome and Gynaecological Cancer Risk.International journal of endocrinology · 2016Review
- Article
- Two major inositol transporters and their role in cryptococcal virulence.Eukaryotic cell · 2011Article
- Article
- Review
- Arabidopsis INOSITOL TRANSPORTER4 mediates high-affinity H+ symport of myoinositol across the plasma membrane.Plant physiology · 2006Article
- Expression studies of GUP1 and GUP2, genes involved in glycerol active transport in Saccharomyces cerevisiae, using semi-quantitative RT-PCR.Current genetics · 2004Article
- Hxt-carrier-mediated glucose efflux upon exposure of Saccharomyces cerevisiae to excess maltose.Applied and environmental microbiology · 2002Article
- Uracil-induced down-regulation of the yeast uracil permease.Journal of bacteriology · 1999Article
- Myo-inositol-dependent sodium uptake in ice plantPlant physiology · 1999Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulation of inositol uptake activity in Saccharomyces cerevisiae during the growth cycle was examined. Activity increased as the cell population transited from lag phase to exponential growth, and continued to increase until late exponential phase. The increase in activity was due to increased transcription of the ITR1 gene and synthesis of the Itr1 permease. When the culture reached stationary phase, uptake activity decreased and dropped to a minimum within 4 h. The decrease was due to repression of ITR1 transcription, independent of the negative regulator Opi1p, and degradation of the existing permease. Degradation depended on delivery of the permease to the vacuole through the END3/END4 endocytic pathway. During exponential growth in inositol-containing medium the permease is also rapidly degraded, whereas in inositol-free medium the permease is highly stable. Rapid degradation of the permease at stationary phase occurred in inositol-free medium, indicating that there are two distinct mechanisms that trigger endocytosis and degradation in response to different physiological stimuli. In addition, the level of the enzyme required for inositol biosynthesis, inositol-1-phosphate synthase, encoded by INO1, is not reduced in stationary-phase cells, and this contrast in the regulation of inositol supply is discussed.
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