ArticleEuropean journal of pediatrics1996
Goldenhar, Möbius and hypoglossia-hypodactyly anomalies in a patient: syndrome or association?
Article in European journal of pediatrics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Article
- Sagittal craniosynostosis with Moebius syndrome; case illustration: first case in the literatüre.BMC pediatrics · 2025Review
- Poland-Möbius syndrome: a case report implicating a novel mutation of the PLXND1 gene and literature review.BMC pediatrics · 2022Review
- A Wide Spectrum of Axial Mesodermal Dysplasia Complex With Rhombencephalic Anomaly: A Case Report.Annals of rehabilitation medicine · 2016Article
- Examining the genetics of congenital facial paralysis--a closer look at Moebius syndrome.Oral and maxillofacial surgery · 2015Review
- Goldenhar Syndrome Associated with Extensive Arterial Malformations.Case reports in pediatrics · 2015Article
- Oromandibular-limb Hypogenesis Syndrome Type II C: A Rare Case.Journal of dental research, dental clinics, dental prospects · 2010Article
- Isolated aglossia in a six year old child presenting with impaired speech: a case report.Cases journal · 2009Article
- A Rare Clinical Variant of Oromandibular Limb Hypogenesis Syndrome Type I B.International journal of clinical pediatric dentistryArticle
- Moebius Syndrome: An Updated Review of Literature.Child neurology openReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledThe Möbius, Goldenhar and hypoglossia-hypodactyly anomalies are usually sporadic conditions with a recurrence risk of about 2%. The combination of Goldenhar and one or the two others is rare, whereas the concomitant occurrence of Möbius and hypoglossia-hypodactyly, and/or Poland, and/or Klippel-Feil anomaly is well known. Pathogenetically, vascular disruptions around the 4th embryonic week have been hypothesized. In vivo and pathological studies as well as animal models support this theory for all the above-mentioned combinations. Whether a preceding blastogenetic alteration is an influencing factor or a disorganization mutation, remains unclear. We describe a 3-year-old girl with bilateral anotia, epidermoid on the right eye, 6th and 7th nerve palsy, hypoglossia, left hypodactyly, and ventricular septal defect.
conclusionWe wish to emphasize the aetiological relevance of vascular disruptions in this previously unreported combination of Möbius, Goldenhar and hypoglossia-hypodactyly anomalies. The concurrence of anomalies in this patient represents an association and not a pleiotropic syndrome.
Indexed as
Identifiers
8741036What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.