ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]1996
Dextran sulfate sodium (DSS) induced experimental colitis in immunodeficient mice: effects in CD4(+) -cell depleted, athymic and NK-cell depleted SCID mice.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
68 citing papers in PubMed, 178 citations in OpenAlex.
- Article
- Article
- Slc11a1 gene polymorphism influences dextran sulfate sodium (DSS)-induced colitis in a murine model of acute inflammation.Genes and immunity · 2023Article
- Dextran Sulphate Sodium Acute Colitis Rat Model: A Suitable Tool for Advancing Our Understanding of Immune and Microbial Mechanisms in the Pathogenesis of Inflammatory Bowel Disease.Veterinary sciences · 2022Article
- Chitosan Oligosaccharides Alleviate Colitis by Regulating Intestinal Microbiota and PPARγ/SIRT1-Mediated NF-κB Pathway.Marine drugs · 2022Article
- Facilitation of colonic T cell immune responses is associated with an exacerbation of dextran sodium sulfate-induced colitis in mice lacking microsomal prostaglandin E synthase-1.Inflammation and regeneration · 2022Article
- 1,25-Dihydroxyvitamin DJournal of cellular physiology · 2021Article
- Irisin attenuates inflammation in a mouse model of ulcerative colitis by altering the intestinal microbiota.Experimental and therapeutic medicine · 2021Article
- Fabrication and Evaluation of Celecoxib Oral Oleogel to Reduce the Inflammation of Ulcerative Colitis.AAPS PharmSciTech · 2021Article
- Article
- The Inflammasome Adaptor ASC Intrinsically Limits CD4Frontiers in immunology · 2019Article
- Effects of Taste Signaling Protein Abolishment on Gut Inflammation in an Inflammatory Bowel Disease Mouse Model.Journal of visualized experiments : JoVE · 2018Article
- The roles of IL-17C in T cell-dependent and -independent inflammatory diseases.Scientific reports · 2018Article
- Immuno-PET in Inflammatory Bowel Disease: Imaging CD4-Positive T Cells in a Murine Model of Colitis.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018Article
- A murine colitis model developed using a combination of dextran sulfate sodium and Citrobacter rodentium.Journal of microbiology (Seoul, Korea) · 2018Article
- Calycosin attenuates dextran sulfate sodium (DSS)-induced experimental colitis.Iranian journal of basic medical sciences · 2017Article
- Intestinal helminth infection drives carcinogenesis in colitis-associated colon cancer.PLoS pathogens · 2017Article
- ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation.Cell death & disease · 2017Article
- Interleukin-33 in health and disease.Nature reviews. Immunology · 2016Review
- Mucosa-reparing and microbiota-balancing therapeutic effect ofExperimental and therapeutic medicine · 2016Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Administration of dextran sulfate to mice, given in the drinking water results in acute or subacute colonic inflammation, depending on the administration protocol. This colonic inflammation exhibits ulceration, healing and repair, and a therapeutic response that makes it valuable for the study of mechanisms that could act in the pathogenesis of human ulcerative colitis, a disease thought to have an immunologically dependent pathogenesis. To investigate if immunological mechanisms were involved in the induction of colonic inflammation in this model, mice with different degrees of immunodeficiency were used. It was shown that dextran sulfate induced colitis could be induced in Balb/c mice depleted of CD4(+) helper T cells by treatment with monoclonal antibodies preceded by adult thymectomy. The depletion of CD4(+) was verified by flow cytometric analysis. Furthermore, the colonic inflammation could equally be induced in athymic CD-1 nu/nu mice lacking thymus-derived T cells, in T and B-cell deficient SCID mice, and also in SCID mice depleted of NK cells by treatment with anti-asialo GM1 antibodies. The NK-cell depletion was verified by measuring spleen NK-cell activity. The resulting colonic inflammation in all these types of deficient mice was qualitatively comparable, as shown by clinical and histological appearance. These results indicate that the presence of functional T, B and NK cells is not crucial for the induction of dextran sulfate colitis in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.