ReviewBreast cancer research and treatment1996
Human breast cancer cell line xenografts as models of breast cancer. The immunobiologies of recipient mice and the characteristics of several tumorigenic cell lines.
Review in Breast cancer research and treatment, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed.
- Exploring bone-tumor interactions through 3DJournal of bone oncology · 2025Review
- Rat Models of Hormone Receptor-Positive Breast Cancer.Journal of mammary gland biology and neoplasia · 2024Review
- Article
- Article
- Neratinib plus trastuzumab is superior to pertuzumab plus trastuzumab in HER2-positive breast cancer xenograft models.NPJ breast cancer · 2021Article
- Role of dietary fat on obesity-related postmenopausal breast cancer: insights from mouse models and methodological considerations.Breast cancer (Tokyo, Japan) · 2021Review
- Review
- Experimental models of endocrine responsive breast cancer: strengths, limitations, and use.Cancer drug resistance (Alhambra, Calif.) · 2021Article
- 90 YEARS OF PROGESTERONE: Progesterone and progesterone receptors in breast cancer: past, present, future.Journal of molecular endocrinology · 2020Review
- Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer.Journal of visualized experiments : JoVE · 2020Article
- Novel Techniques to Study the Bone-Tumor Microenvironment.Advances in experimental medicine and biology · 2020Review
- Establishment of chemosensitivity tests in triple-negative and BRCA-mutated breast cancer patient-derived xenograft models.PloS one · 2019Article
- Nicotine associated breast cancer in smokers is mediated through high level of EZH2 expression which can be reversed by methyltransferase inhibitor DZNepA.Cell death & disease · 2018Article
- ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin.Nature communications · 2017Article
- Steroid Hormone Receptor Positive Breast Cancer Patient-Derived Xenografts.Hormones & cancer · 2017Review
- Patient-derived xenograft (PDX) models in basic and translational breast cancer research.Cancer metastasis reviews · 2016Review
- Role of dietary bioactive natural products in estrogen receptor-positive breast cancer.Seminars in cancer biology · 2016Review
- Peptide Hydrogels - Versatile Matrices for 3D Cell Culture in Cancer Medicine.Frontiers in oncology · 2015Review
- A reconstructed metastasis model to recapitulate the metastatic spread in vitro.Biotechnology journal · 2014Article
- A renewable tissue resource of phenotypically stable, biologically and ethnically diverse, patient-derived human breast cancer xenograft models.Cancer research · 2013Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
The ability to maintain and study human tissues in an in vivo environment has proved to be a valuable tool in breast cancer research for several decades. The most widely studied tissues have been xenografts of established human breast cancer cell lines into athymic nude mice. Human breast tumor xenografts provide the opportunity to study various important interactions between the tumor and host tissues, including endocrinologic, immunologic, and tumor-stroma interactions. The nude mouse is not the only immune-deficient recipient system in which to study xenografts. Additional single and combined mutant strains have been used successfully, including mice homozygous for the severe combined immune deficiency mutation (scid), both the beige (bg) and nude (nu) mutations in combination (bg/nu), and mice bearing the combined bg/nu/xid mutations. The differing immunobiologies are discussed, with particular reference to the immunobiology of breast cancer, as are the characteristics of several of the more frequently utilized breast cancer xenografts and cell lines. The ability of several endocrine treatments to modulate effectors of cell mediated immunity, e.g., estrogens and antiestrogens, and the effect of site of inoculation on tumor take and metastasis, also are described.
Indexed as
Identifiers
8738607What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.