Evidence map›Paper›PMID 8738601›Full record

ReviewBreast cancer research and treatment1996

Animal models of breast cancer: their diversity and role in biomedical research.

R Clarke

Abstract readReview
PubMed Publisher
In one paragraph

Review in Breast cancer research and treatment, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Patient-derived human tumour tissue xenografts in immunodeficient mice: a systematic review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2010
    Pooled it
  3. Successful hormonal and chemical induction of prostate cancer in a rat model: practical guidelines.Veterinary research forum : an international quarterly journal · 2024
    Review
  4. Large Animal Models of Breast Cancer.Frontiers in oncology · 2022
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Animal models of breast cancer for the study of pathogenesis and therapeutic insights.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2009
    Review
  13. Article
  14. Mouse models in oncogenesis and cancer therapy.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2006
    Review
  15. Review
  16. Review
  17. Review
  18. The role of stroma in breast carcinoma growth in vivo.Journal of mammary gland biology and neoplasia · 1998
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

R ClarkeVincent T. Lombardi Cancer Center, Georgetown University Medical School, Washington DC 20007, USA.
Georgetown University · US

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI STEPHEN W BYERS · 1990 to 2026
$71.5M
SPORE IN BREAST CANCERP50CA058185 · NCI · GEORGETOWN UNIVERSITY · PI DICKSON, ROBERT B. · 1992 to 2004
$4.0M
ESTROGEN-INDUCED PROGRESSION IN HUMAN BREAST CANCERR01CA058022 · NCI · GEORGETOWN UNIVERSITY · PI CLARKE, ROBERT R. · 1992 to 2001
$445k
NCI NIH HHS P30-CA51008NCI NIH HHS P50-CA58185NCI NIH HHS R01-CA58022
6 · The paper itself

Abstract

Animal models of breast cancer have been widely used to study various aspects of breast cancer biology, and are remarkably diverse, encompassing chemically and virally induced tumors, human tumor xenografts, and transgenic mouse models. Several novel models have become available during the past few years, including tumors induced by polyomavirus and adenovirus, and a series of human cell line variants. The several following articles describe, in some detail, the characteristics of these models and their relevance to the human disease. Descriptions of each of the major models, e.g., 7,12-dimethylbenz(a)anthracene-induced, MMTV-associated, and human breast cancer cell line xenografts, also are included. The limitations and advantages of several of these models, and some issues relating to the choice of models, are briefly discussed in this overview.

Indexed as

Breast NeoplasmsDisease Models, AnimalMammary Neoplasms, ExperimentalAnimalsAnimal WelfareFemaleHumansMiceMice, Transgenic

Identifiers

PMID8738601
OpenAlexW2095475850

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.