ArticleParasitology research1996
Investigations into the production and function of leukotrienes during histotropic development of Oesophagostomum dentatum.
Article in Parasitology research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 23 citations in OpenAlex.
- Cracking the nodule worm code advances knowledge of parasite biology and biotechnology to tackle major diseases of livestock.Biotechnology advances · 2015Review
- A study on in vitro culture of Trichuris ovis in different physiological solutions at constant temperature, 37°C.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2011Article
- Ecdysis of Oesophagostomum: possible involvement of eicosanoids and development of a bioassay.Parasitology research · 2005Article
- Production of eicosanoids and other oxylipins by pathogenic eukaryotic microbes.Clinical microbiology reviews · 2003Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dynamics of production and excretion of leukotrienes by parasitic larvae of Oesophagostomum dentatum and their role for the development of the larvae were studied. Larvae were cultured in vitro to the fourth stage (L4). Leukotriene B4 (LTB4) was detected in homogenates and in supernatant of larvae, with the homogenate-protein-based values steadily decreasing during development. The homogenate-protein-based values of peptidyl leukotrienes (pepLT) remained fairly stable in both homogenates and supernatants, whereas the wormcount-based pepLT values increased significantly. The addition of diethylcarbamazine (DEC) to the culture medium straight from the beginning of culturing (12.8 or 25.5 mmol/l) reversibly hampered growth and development to L4. Application of DEC at 12.8 mmol/l beginning on day 13 of in vitro cultivation exerted no significant effect on further development to L4. LTB4 appeared to counteract the inhibition of development by DEC. The results of this study indicate that endogenous LTs participate in regulation of the growth and development of O. dentatum.
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Registered trials
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