ArticleAnatomy and embryology1996
In vivo inhibition of programmed cell death by local administration of FGF-2 and FGF-4 in the interdigital areas of the embryonic chick leg bud.
Article in Anatomy and embryology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 64 citations in OpenAlex.
- Transient cartilages and interdigital vasculature organization in the embryonic duck foot.Royal Society open science · 2026Article
- Article
- Genetic determinants of syndactyly: perspectives on pathogenesis and diagnosis.Orphanet journal of rare diseases · 2022Review
- Regulation of the limb shape during the development of the Chinese softshell turtles.Evolution & development · 2020Article
- BMPs are direct triggers of interdigital programmed cell death.Developmental biology · 2016Article
- Interleukin-driven insulin-like growth factor promotes prostatic inflammatory hyperplasia.The Journal of pharmacology and experimental therapeutics · 2014Article
- Smad1/Smad5 signaling in limb ectoderm functions redundantly and is required for interdigital programmed cell death.Developmental biology · 2012Article
- Alternative cell death mechanisms in development and beyond.Genes & development · 2010Review
- Antagonistic crosstalk of Wnt/beta-catenin/Bmp signaling within the Apical Ectodermal Ridge (AER) regulates interdigit formation.Biochemical and biophysical research communications · 2010Article
- Genetic control of programmed cell death during animal development.Annual review of genetics · 2009Review
- Interdigital webbing retention in bat wings illustrates genetic changes underlying amniote limb diversification.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Perspectives on hyperphalangy: patterns and processes.Journal of anatomy · 2004Review
- YY1 activates Msx2 gene independent of bone morphogenetic protein signaling.Nucleic acids research · 2002Article
- Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice.Genes & development · 1998Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The formation of the digits in amniote vertebrates is accompanied by a massive degeneration process that accounts for the disappearance of the interdigital mesenchyme. The establishment of these areas of interdigital cell death (INZs) is concomitant with the flattening of the apical ectodermal ridge (AER), but a possible causal relationship between these processes has not been demonstrated. Recent studies have shown that the function of the AER can be substituted for by implantation of beads bearing either FGF-2 or FGF-4 into the apical mesoderm of the early limb bud. According to these observations, if the onset of INZs is triggered by the cessation of the AER function, local administration of FGFs to the interdigital tissue prior to cell death should delay or inhibit interdigit degeneration. In the present study we have confirmed this prediction. Implanting Affi-gel blue or heparin beads pre-absorbed with either FGF-2 or FGF-4 into the interdigital tissue of the chick leg bud in the stages prior to cell death stimulates cell proliferation and causes the formation of webbed digits. Vital staining with neutral red confirmed an intense temporal inhibition of interdigital cell death after FGF treatment. This inhibition of interdigital cell death was not accompanied by modifications in the pattern of expression of Msx-1 or Msx-2 genes, which in normal development display a domain of expression in the interdigital tissue preceding the onset of degeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.