ArticleThe Journal of physiology1996
In vivo synchronous membrane potential oscillations in mouse pancreatic beta-cells: lack of co-ordination between islets.
Article in The Journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 68 citations in OpenAlex.
- Ultrafast multicellular calcium imaging of calcium spikes in mouse beta cells in tissue slices.Acta physiologica (Oxford, England) · 2025Article
- Monolayer whole adherent islets: A novel tool for studying drug-induced diabetic phenotypes in vitro.PloS one · 2025Article
- CaAmerican journal of physiology. Endocrinology and metabolism · 2023Review
- Network Properties of Electrically Coupled Bursting Pituitary Cells.Frontiers in endocrinology · 2022Article
- "Take Me To Your Leader": An Electrophysiological Appraisal of the Role of Hub Cells in Pancreatic Islets.Diabetes · 2020Review
- Review
- Critical and Supercritical Spatiotemporal Calcium Dynamics in Beta Cells.Frontiers in physiology · 2017Article
- Bursting synchronization dynamics of pancreatic β-cells with electrical and chemical coupling.Cognitive neurodynamics · 2013Article
- Glucose-stimulated calcium dynamics in islets of Langerhans in acute mouse pancreas tissue slices.PloS one · 2013Article
- Functional connectivity in islets of Langerhans from mouse pancreas tissue slices.PLoS computational biology · 2013Article
- Bursting and calcium oscillations in pancreatic beta-cells: specific pacemakers for specific mechanisms.American journal of physiology. Endocrinology and metabolism · 2010Review
- Functional roles for noise in genetic circuits.Nature · 2010Review
- An islet population model of the endocrine pancreas.Journal of mathematical biology · 2010Article
- Accounting for near-normal glucose sensitivity in Kir6.2[AAA] transgenic mice.Biophysical journal · 2009Article
- Novel aspects of the molecular mechanisms controlling insulin secretion.The Journal of physiology · 2008Review
- RyR channels and glucose-regulated pancreatic beta-cells.European biophysics journal : EBJ · 2008Article
- Investigating the role of islet cytoarchitecture in its oscillation using a new beta-cell cluster model.PloS one · 2007Article
- Effects of both glucose and IP3 concentrations on action potentials in pancreatic beta-cells.European biophysics journal : EBJ · 2007Article
- Diffusion of calcium and metabolites in pancreatic islets: killing oscillations with a pitchfork.Biophysical journal · 2006Article
- Stabilizing role of calcium store-dependent plasma membrane calcium channels in action-potential firing and intracellular calcium oscillations.Biophysical journal · 2005Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The properties of the oscillations in electrical activity of different beta-cells within the same islet of Langerhans, and of different islets within the same pancreas, recorded in vivo, are described. 2. Simultaneous recordings of two cells within the same islet showed that the oscillations were synchronous. A rapid increase in blood glucose led to the simultaneous appearance of a transitory phase of continuous electrical activity in both cells. These results indicate that under physiological conditions, the islets operate as a functional syncytium. 3. Simultaneous recordings of cells from two different islets within the same pancreas showed that the oscillations in the electrical activity were not synchronous, which suggests that each islet is a functionally independent unit. Rapid changes in blood glucose led to the appearance of a transitory phase of increased electrical activity in both islets, although of different duration. These results suggest that the endocrine pancreas lacks a pacemaker driving the electrical activity of all the islets. 4. The comparison of the degree of activation of different islets, simultaneously recorded at different glucose concentrations, indicated that all the islets had a similar sensitivity to glucose. Furthermore, when the glucose concentration was increased, the electrical activity in both islets increased in parallel, suggesting that the amount of insulin released due to the increase in glycaemia was produced by the simultaneous response of all the islets and not by the recruitment of islets with different sensitivities to glucose. 5. Our results predict that the synchronous electrical activity of all the cells within an islet will result in widespread intracellular calcium oscillations and pulsatile insulin secretion. The periodicity of the pulses of insulin secretion in different islets is suggested to be of slightly different length and asynchronous.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.